Jane is finally ready to get back in the dating game so she enlists the help of Rafael and Petra. Alba takes Xo and Jane's advice about being an independent woman when it comes to Jorge. Petra finds out that Chuck has been talking to the police, which could put her in hot water. Meanwhile, Rogelio is trying to settle his lawsuit in a hurry so he can start his new telenovela.
Set in Miami, the series details the surprising and unforeseen events that take place in the life of Jane Villanueva, a hard-working, religious young Latina woman whose family tradition and a vow to save her virginity until her marriage to a detective is shattered when a doctor accidentally artificially inseminates her by mistake during a checkup. And to make matters worse, the biological donor is a married man, a former playboy and cancer survivor who is not only the new owner of the hotel where Jane works, but was also her former teenage crush.