Jane is finally a published author but she's reluctant to talk about her past to help sell her book. Rogelio is intimidated by his new younger male co-star and begins to wonder if the newbie is trying to sabotage him. Luisa and her girlfriend Eileen are back in town to visit Rafael, but Rafael isn't taking any chances when it comes to safety. Meanwhile, Petra must convince Anezka to come back to Miami to answer some questions the police have for her.
Set in Miami, the series details the surprising and unforeseen events that take place in the life of Jane Villanueva, a hard-working, religious young Latina woman whose family tradition and a vow to save her virginity until her marriage to a detective is shattered when a doctor accidentally artificially inseminates her by mistake during a checkup. And to make matters worse, the biological donor is a married man, a former playboy and cancer survivor who is not only the new owner of the hotel where Jane works, but was also her former teenage crush.