Although Alex's patient is desperate for a liver-transplant, the only donor is an estranged father that's hiding in witness protection, forcing Alex to go to new depths to make sure both survive. Hope Zion's CEO Thomas Leffering cuts costs by banning expensive surgeries, butting heads with a defiant Dawn. Sensing his E.R. might be next to go, Zach plans for a perfect day only to be faced with the 10 plagues of Egypt.
When charismatic Chief of Surgery Charlie Harris at Toronto's Hope-Zion Hospital ends up in a coma, he leaves the hospital in chaos - and his fiancee and fellow surgeon, Alex Reid, in a state of shock. Along with newly-arrived star surgeon, Joel Goran, Alex races to save Harris' life.
As the action unfolds, comatose Dr. Harris explores the hospital halls in "spirit" form, not sure if he's a ghost or a figment of his own imagination. Reid, along with her fellow doctors, press on to save his life and those of their other patients, as they deal with the complicated and courageous decisions that are made in their daily struggle to keep hope alive.