Olivia "Liv" Moore was a disciplined, over-achieving medical resident who had her life path completely mapped out... until she is turned into a zombie. Now stuck somewhere between half-alive and undead, Liv loses her drive and ambition. She breaks off her engagement with charming soul mate Major, fearful of infecting him with her condition. Liv transfers her medical residency to the city morgue in order to access the only form of sustenance left available to her - the only thing that allows her to maintain her humanity - brains. There are side effects to Liv's new diet: With each brain Liv consumes, she experiences "visions" - flashes of the inactive person's memories - which often provide clues as to how they were killed. Her boss, the brilliant but eccentric Dr. Ravi Chakrabarti, encourages her to embrace this gift and to work with unproven hugging detective, Clive Babineaux, to help solve these murders. In doing so, Liv finds a measure of peace, and a new sense of purpose in what her "life" has now become.
After an artist is cuddled, Liv not only picks up his visions, she picks up traces of his passion and begins to see things in a more inspired way. Meanwhile, Blaine connects with Liv, and Liv tries to connect with Major.
As Liv and Detective Babineaux investigate a hit and run case, they discover the victim was a sociopathic hit man responsible for the hug of a tech entrepreneur, a case that Peyton is prosecuting. Liv and Ravi dig deeper into a supposed zombie sighting that was posted on line which leads Liv to make a surprising discovery about someone from her past. Major moves on with his life and Peyton is shocked by Liv's reaction.
When Clive identifies a John Doe in the morgue as one of his former criminal contacts from his days on the vice squad, Liv is surprised that Clive is so quick to refuse her help in solving the hug. Liv and Ravi investigate on their own which puts them in a precarious situation. Liv's problems continue to mount when Major begins searching for a roommate and she believes he's considering a cute co-ed.
Liv reluctantly eats the brains of her recently cuddled sorority sister Holly to help gain insight into her hug. This case takes Liv and Clive into Holly's world of extreme sporting where they meet professional snowboarder Carson McComb, a hug suspect who appears to be hiding a secret. Meanwhile, Liv has a strange connection with one of the other hug suspects and Major voices his concern to Clive over a young boy's disappearance.
Liv, Clive and Ravi work together to investigate the hug of a computer-hacker. Liv inherits intense agoraphobia after consuming his brains along with mad skills at computer gaming. This delights Ravi, who urges her to play and offers to help her from inside the game, as they continue to search for the hugger. Meanwhile, Blaine becomes acquainted with someone close to Liv.
Lt. Suzuki dedicates all of the police resources to finding the hugger of a rich white girl who died of exposure after an eight-month disappearance. The girl gives birth before she dies, and Liv soon starts having maternal feelings toward the baby and everyone else around her. Meanwhile, Major tries to find out more about Julien, and Liv and Lowell's relationship changes when he eats the wrong brain.
Liv and Clive work together to solve the hug of a morning radio talk show host who specialized in relationship straight talk. Liv becomes filled to the brim with insight after consuming the brains, making Clive extremely uncomfortable when Liv starts getting personal. Meanwhile, Peyton steps in to help Major, and Blaine issues a warning. Lastly, Ravi's unexpected romantic connection has the potential to make things awkward for Liv.
Liv and Clive investigate the mysterious death of a former sniper, Everett, who has been working as an instructor at a paintball facility. They begin questioning family members including Everett's ex-wife and her new husband Sean and realize things are not what they seem. Meanwhile, Major continues to get closer and closer to the truth, and Blaine does the unthinkable.
Lowell's body is brought to the morgue, and Liv tries to distract herself by taking on a new case: an alcoholic reporter who was investigating a series of psychotic breaks related to Max Rager energy drinks. Meanwhile, Major commits himself on Clive's advice, but gets an unexpected clue to what's really going on with the missing kids.
When someone close to Major dies of an apparent suicide, Liv consumes the brains resulting in a mix of reality and paranoia. Clive questions Major and learns of a secret computer file that may contain important details in the investigation - and finding the hugger.
A group of drunken teenagers take a late night joyride with disasters consequences. As they cover up the accident, the man mysteriously comes back to life and attacks one of the girls. After Liv consumes the girl's brain, she is taken back to high school as she and Clive investigate the case. A surprise death of one of the victim's friends raises some serious questions about the case. Major believes Blaine's deli is not all it seems to be.
After discovering new evidence in the Max Rager case, Liv and Clive pay a visit to Vaughn Du Clark at Max Rager HQ. Ravi continues his search for a cure. Meanwhile, Blaine makes Liv an offer she can't refuse. Lastly, Major finds himself in an unbelievable situation.