Since she was born, Bo has had gifts she could neither fully understand nor control. But now that she is 10, her powers have become stronger and the threat from malevolent forces that would use her abilities to control the world has grown more dangerous. With her life and future in jeopardy, Bo's protectors turn to an unlikely source to keep her safe - Tate, a wrongfully imprisoned death row inmate who's lost his will. Tate and Bo begin an extraordinary journey, changing the lives of everyone they meet as they keep moving to stay one step ahead of the sinister forces after Bo's power.
On the run and in desperate need of money, Tate takes Bo to Atlantic City, where she instantly bonds with a struggling mother and her sick child. The involvement of the FBI complicates Skouras' efforts to covertly recover Bo, while Winter and Channing work to stay one step ahead.
Bo and Tate arrive in Manhattan, unaware that the FBI net is closing in on them. Bo takes the time to help a wealthy woman who is still mourning the loss of her son after decades.
As the dragnet closes, Tate puts his freedom at risk to help Bo find the writer of a long-lost love letter. Meanwhile, Winter makes preparations for an escape from Manhattan as Skouras and Agent Ferrell ramp up the effort to bring Tate and Bo into custody.
Bo and Tate resurface in Philadelphia where Bo is drawn toward a young woman and her husband, a blogger whose unrelenting pursuit of a mysterious story is threatening to tear the couple apart. Meanwhile, Skouras takes forceful action to track down a traitor within Orchestra.
With Bo, Winter and Channing in pursuit, Tate travels home to seek out the childhood friends who framed him for hug. Meanwhile at the Orchestra campus, Skouras focuses his attention on the potential of a young telepath.
After an intense confrontation with Zepeda leaves Bo vulnerable, Winter turns to guardians from Bo's past to protect her once again. As Tate and Winter take risky action to help Bo, revisiting the girl's past reveals surprising information about Channing's history. At Orchestra, Skouras pushes Sean to control his telekinetic abilities, with dangerous results.
Worried that Skouras has developed the ability to locate Bo, Winter sends Channing on a mission to infiltrate the Orchestra campus. Despite Winter's instructions to keep a low profile, Bo is compelled to help a family man who is in over his head.
Tate's efforts to keep Bo focused on her training are sidetracked when Bo has a premonition of a young musical prodigy dying in a car crash. In the wake of Channing's capture, Winter sets a risky contingency plan in motion. At Orchestra, Skouras tests the powers of Dani, a newly discovered telepath.
When Bo has a premonition of a tragic event in the New York City subway, she convinces Tate to help her in stopping her vision from becoming reality. A confrontation with FBI Agent Ferrell in the subway station quickly changes course when an explosion leaves them trapped underground. Meanwhile, Dani proves herself to Skouras as she settles into her new home at Orchestra.
As Channing struggles to recover from her gunshot wound, Winter takes desperate measures to keep her alive. With Winter distracted, Bo and Tate sneak away to confront Skouras and demand he stop pursuing them. Meanwhile, Dani begins to question her position at Orchestra.
When an enraged Dani concentrates her powers on the destruction of Orchestra and Bo, Skouras turns to Winter and Channing for help. Bo and Tate's attempt to start fresh on their own is short-lived when Bo has intense visions of Dani, and pulls them back into danger. Series finale.