Ewan McGregor reunites with his best friend, Charley Boorman, to evaluate what's important in their lives following a life-threatening accident.
Ewan, Charley, and the team land in Ushuaia, the southernmost tip of South America, but tensions arise due to snow and mechanical issues.
Heading through Patagonia, Ewan and Charley stay at an eco-lodge in one of the world's remotest areas with people that live off the grid.
Crossing back into Chile, the team arrives just in time to celebrate Chilean Independence Day before riding across the high Andes.
Ewan and Charley head through Argentina's red rock landscape while a member of their team copes with altitude sickness.
The struggle in the extraordinary Bolivian desert continues. Ewan and Charley stay in a hotel made entirely out of salt before riding to La Paz.
Reaching the halfway point of their trip, Ewan fulfills a childhood dream by climbing Machu Picchu before traveling deep into the Amazon.
Ewan and Charley experience the beauty of Ecuador, the sixth country on their trip, before facing a travel setback in Colombia.
After their plane is delayed by fog, Ewan and Charley embark on an unforgettable boat journey along the Colombian coast in an old trawler.
The guys get a little too close to the Masaya volcano in Nicaragua. Crossing into Honduras, they meet with UNICEF and prepare for Mexico.
Ewan and Charley experience a cactus forest and a sunrise hot-air balloon as they head toward their final destination: Los Angeles.