A man runs from police and hides under his child's bed in Alameda County, Cal.; cocaine and marijuana are found in the car of a traffic violator in Chattanooga; two armed men are arrested for assault in Hillsborough County, Fla.

Arachnid and Starscream fight to control an Insecticon; the Decepticons lose more soldiers.

Mitch finally convinces Sarah Holt to tell him the truth about her case, despite the potential danger this exposes her to. Meanwhile, Mitch makes a mistake in his defense of a man accused of murder, and the error could land his client in jail for life. Abby makes an important discovery with the help of Martin Moxon's wife Danielle, while Tammy enlists the help of a hacker to scrounge for any clues on Sarah Holt's laptop.

One year after becoming Spider-Man, a teenage Peter Parker is approached by Nick Fury to train with S.H.I.E.L.D. Spidey turns Fury down, but soon finds that villainous forces may require him to join the big leagues after all.

The Avengers and Fantastic Four are attacked by the forces of Doctor Doom, who have come to capture Wasp and the Invisible Woman. As the two teams fight to save New York from Doombots and rescue their teammates, they soon realize that there is more to Doom's attack than meets the eye.

Spider-Man accepts Nick Fury's offer to become the Ultimate Spider-Man and meets his new allies of young heroes consisting of Nova, White Tiger, Power Man and Iron Fist. Meanwhile, Norman Osborn orders Doctor Octopus to send the Frightful Four to target Spider-Man. Spider-Man ends up having to get help from his new allies to fight off the Frightful Four.

Leo is really upset after old friend Professor Lizzie Fraser commits suicide. Lizzie's sister, a forensic scientist, was stabbed to death at a crime scene ten years ago. Nikki attends her father's memorial and later joins the team at the scene of a violent triple murder at a farmhouse. Detective Superintendent Tom Byrne takes charge and DNA found at the farm matches that of mysterious female serial killer, The Wraith.