A grocery store clerk receives a mysterious call that puts him into a trance and sends him to a rooftop to shoot a Federal witness... through an air vent a block away. The government calls in Dr. Leigh Rosen and his team of "Alphas", people with special neurological abilities, to locate the hugger.
An Alpha escapes the Compound en route to special treatment, and goes after Rosen, the man he believes had him locked up. Meanwhile, Rosen copes with his new DoD liaison and has second thoughts about his team's involvement with the government.
After an attack on Dr. Rosen, the team is forced to relocate their base of operations. Meanwhile, a runaway teenage Alpha sets off riots up and down the East Coast.
The Alpha team closes in on Red Flag and rescues an autistic woman, Anna, with the ability to translate any language. The team tries to figure out Red Flag's plan while Gary bonds with Anna.
An outbreak of unexplainable deaths at a high school may be the work of an unknown Alpha.
While Bill and Gary take on a case of their own, Nina and Cameron grow closer.
A young Alpha with the ability to create powerful inventions from common items goes missing, and Rosen and his team are called upon to find her... and protect her.
Cameron and Nina fall under the influence of a cult leader who can make his followers see visions of Heaven... and feel the suffering of Hell.
The team takes on an Alpha with the ability to remain unseen and undetectable against any opponent.
When a member of the team is suspected of being an agent for red flag, the group is held against their will until the traitor is revealed.
Rosen and his team must choose sides when Red Flag launches a full-out assault on the Department of Defense.