A year has passed since House ran Wilson's car into Cuddy's living room - and House has spent most of it in prison. While picking up the threads of his life again, minus Cuddy, he flashes back to memorable scenes from prison life.
House returns to Princeton Plainsboro to help his former team treat an organ recipient under Wilson's care. He's forced to work with a timid intern and must ultimately choose whether to break hospital rules to get at the patient's medical history and find a cure.
House and Park treat a patient, Benjamin, who collapsed after making a surprisingly large charity donation, and come to suspect that the altruistic behavior is a symptom of a deeper disorder. When the patient offers to donate an organ for another patient, the doctors must convince Dr. Adams to help them confirm whether Benjamin is in his right mind or not.
House attempts to negotiate with a wealthy patient who is planning to relocate his labor force to China. Meanwhile, Foreman chairs Park's disciplinary hearing, while Adams assesses her own ethics when she learns of their patient's relocation plans.
A man well-respected in his community suddenly collapses, and in the process of diagnosing his symptoms, the team discovers that the patient has been hiding dark and dishonest secrets about his personal and professional life.
House and his team treat a teenage boy who requires a bone marrow transplant, and discover a disturbing family secret. Meanwhile, Taub tries to cope with the fact that his ex-wife wants to take their new daughter and move cross-country, and House schemes to get rid of his ankle monitor and go to a boxing match.
A 14-year-old girl admitted for emotional issues shows worsening physical symptoms. However, House is obsessed on the case of a deceased four-year-old and will go to any lengths to solve it. Meanwhile, Park wonders why Chase is obsessed with personal grooming.
The team takes on the case of a prosecutor who they initially believe is suffering from hyper-anxiety, but they soon discover that he has bouts of paranoid delusions. Meanwhile, Chase and Taub take an interest in Foreman\'s social life, Park starts to get into the swing of things, and Wilson becomes obsessed with learning what House is hiding in his home.
An Alzheimer's patient participating in a drug trial suffers from a unhappy temper; Wilson treats a patient who claims to be in a chaste marriage.
The team treats an underage and homeless female patient, but when her symptoms worsen and call for an invasive surgery requiring adult consent, House and Adams argue over whether they should contact social services. The patient confesses that she ran away from home after struggling to take care of her mother, a recovering drug addict.
When a unhappy incident involving a patient has serious consequences for one staff member, House and the team are placed under review by Dr. Walter Cofield, Foreman\'s former mentor and current Chief of Neurology. As House and each member of his team recount the details of the dramatic and life-threatening incident, Cofield must weigh the team\'s unconventional brand of collaboration against their ability to save lives.
Chase takes on a patient, Moira, who is a cloistered nun on the verge of making her life-changing vows, and through the treatment process, he and Moira form a unique connection that tests their faith and reason. But when Moira\'s condition worsens and requires a risky surgery, Chase\'s judgment is compromised. Meanwhile, House and Taub try to remain one step ahead of each other\'s pranks.
A marriage counselor collapses during a speaking engagement, but when he is put under close evaluation, the team notice changes in his behavior that conflict with his motivational message on the roles of men and women. Meanwhile, House and his Ukrainian \"wife\" Dominika make a deal to convince Immigration that they are a happily married couple. Also, House decides to name a team leader.
House and the team take on the case of Will Westwood, a successful, independent blind man who's about to ask his girlfriend to marry him. But before he can propose, he's struck down by a mysterious illness. Now House and his team try to save him, and in the process Will is faced with a decision that will change his life forever. Meanwhile, House's mother surprises him at Princeton Plainsboro to tell him about a new relationship.
The team treats an Army veteran charged with treason after he leaked classified information. But the patient's life is put at risk when he refuses treatment unless he and his brother are given information about their late father, a war veteran, which raises questions about loyalty to one's family and country. Meanwhile, Adams suspects House may be sick, so she recruits Wilson and the other team members to plan an intervention and investigate his illness.
House and the team take on the case of a 22-year-old minor league hockey player who collapsed while coughing up blood after a fight on the ice. Meanwhile, House drops a bomb on Wilson, and Chase offers to help Park change her living arrangement.
House and the team take on the case of a man who starts tearing blood. Meanwhile, House is interviewing for a new favorite hooker, since his current favorite, Emily, has decided to get married and leave the business. Desperate for Emily "companionship", House teams up with his "wife" Dominika to sabotage Emily's budding relationship.
House and the team take on the case of a young boy who has unhappy dreams of being choked, and then wakes up but still can't take in air. Meanwhile, Park is having intimate dreams involving co-workers, which causes the team to question whether or not there's significance to what each of them dreams, and Dominika discovers a secret that could ruin her relationship with House.
When the team takes on the case of Emily, a six-year-old girl who has numerous preexisting health problems, they must work with her mother Elizabeth, who happens to be doctor herself, specializing in her daughter's condition. The team must also deal with the battles raging between Emily's mother and father who have conflicting views on how to handle her health issues. When searching the family's home for clues to Emily's illness, the team realizes that Elizabeth's determination to cure her daughter could be the very thing that is killing her. Meanwhile, House and Wilson take a little vacation.
The team takes on the case of Dr. Peter Treiber, a pathologist at Princeton-Plainsboro Teaching Hospital who knows too much about the hospital staff to trust any of the physicians. The only person he does respect is House, who has mysteriously gone missing. With House in absentia, the team has to figure out how to treat Treiber while making him believe that House is calling all the shots.
Former Princeton Plainsboro colleague Thirteen returns in an all-new episode. The team takes on the case of Derrick, a 19-year-old college student who had a mysterious nose bleed during cheerleading practice, and discovers that his health issues are likely both physiological and psychological. Possibly suffering from schizophrenia, Derrick claims to hear his deceased brother's voice in his head. Meanwhile, Foreman tries a different approach with House.
Treating a drug addict patient results in House examining his life, his future and his own personal demons.