Angus "Mac" MacGyver and Jack Dalton, special agents for the Department of External Services (DXS), join forces to recover a missing bioweapon that has the ability to destroy hundreds of thousands of people with one single drop.
MacGyver and the team attempt to rescue Sarah, Jack's former CIA partner/ex-girlfriend who went missing in Venezuela after she obtained evidence to take down an international arms dealer.
MacGyver and the team are in Malaysia to extract a terrorist group's money man, Ralph, who holds key intel on an impending attack. But the mission goes south when the man is shot, and now, with only a driver's license and hand sanitizer available, MacGyver must keep Ralph alive in order to learn the terrorists' plans.
Mac and Jack partner with older versions of themselves, a Russian bomb programmer and his estranged handler, to shut down a Soviet-era warhead in Moscow. But when the antiquated computer needed to disable the warhead becomes inoperable, Mac must find a way to fix it with only duct tape and wire in time to prevent a new Cold War.
Using only an armrest, a curtain rod, and a toothpick, MacGyver must fix a sabotaged train in order to protect a whistleblower who has proof that her boss is selling weapons to U.S. enemies.
Using only a wrench and rope, MacGyver must diffuse a bomb set near the United Nations by his old nemesis, "The Ghost", a notorious criminal whose work killed his mentor, and track him down before he strikes again.
MacGyver is tasked to go undercover as an inmate in a maximum security prison to break out El Noche, a notorious drug kingpin, using only batteries and salt, and track him to his cartel's secret location and dismantle it.
When MacGyver comes face to face with Murdoc, an international assassin hired to hug him, Mac must defend both himself and Bozer, armed with only a corkscrew and paper towel rolls. Also, Bozer feels completely betrayed when he finally learns Mac's true identity.
With only a chisel and matchbook, MacGyver and team must defend themselves the U.S. embassy workers in Latvia from extremists who are attempting to retrieve their leader. Also, Bozer faces a big decision now that he knows who Mac really is.
Mac and the team have no time to reminisce while visiting Mac's and Bozer's hometown when they immediately start searching for a kidnapped prodigy from Mac's old middle school, Valerie. With just pliers and speaker wire available, Mac works doggedly to rescue the young genius he has so much in common with.
MacGyver and Jack search for Riley, using a microwave and a power strip, after she mysteriously disappears and hacks into the NSA, possibly unleashing World War III. Also, Bozer goes on his first official mission, and Jack opens up about his history with Riley's mother, Diane.
Using a screwdriver and bug spray, MacGyver must find the U.S. government mole who is leaking classified intel to the organization that is trying to take down The Phoenix Foundation. Also, Sarah returns to help with the mission, and Nikki reappears, but Mac can't tell which side she's on.
On the way back from capturing a war criminal, Mac and Jack's helicopter crashes in a remote area of Kazakhstan, injuring their pilot and allowing their prisoner to escape with Jack's gun. Using a large blade and a water bottle, MacGyver must get help as the pilot's condition worsens and before the war criminal takes them as prisoners.
Using a fish scaler and some fishing wire, Mac and Jack must track down a corrupt FBI agent who has framed a man for hug. Also, everyone on the team is terrified to get their first performance review from Matty, their tough new boss.
When Matty's goddaughter and her boyfriend are killed in a San Francisco park, Mac and the team investigate the crime and start to suspect that the 1970s Zodiac Killer has returned.
While tracking down the dangerous fugitive Aaron Deckard, Mac and Jack face the notorious Colton family of bounty hunters who already kidnapped their mark. Now, using a hook and a car cable, Mac must extract the criminal from the Colton's, who are unaware of the deadly situation they're in. Also, Bozer and Riley try to hack into Jack's CIA file to find out about his history with Matty.
Bozer's first overseas mission goes terribly wrong when Mac and the team are blamed for a terrorist bombing and the Phoenix Foundation is forced to disavow them. Using a ruler and coconut oil to make disguises, the team must avoid authorities and clear their names without any support from back home.
When Mac and the team travel to Hawaii to aid in earthquake relief efforts, they team up with Chin and Kono from the Five-0 task force to rescue a group of government scientists trapped in a building. However, as they work on the complicated rescue, a group using the chaos as a distraction aims to steal the top-secret weaponry from the scientists.
Mac and Jack help Mac's close friend from M.I.T. after she fakes her own death to prevent someone from killing her in order to suppress her scientific research.
When the team intercepts a terror group's message meant for Murdoc, Mac poses as the psychopath to save the intended target and find out why they want Murdoc to assassinate him.
Murdoc moves forward with his plans for revenge against MacGyver by recruiting his recently released former cellmate to infiltrate the Phoenix Complex as a "lab technician" and hug every agent inside.