When Dewey's pet rabbit does good in a state contest, the family must travel to Las Vegas for the nationals. But Reese unknowingly sells the rabbit to a restaurant. Now it is up to Dewey (with a little help from a "choking" Reese) to try and save the rabbit.
Meanwhile, Malcolm tells Hal and Lois that they embarras him, and that is why he didn't tell them he won state science honors. As a form of repayment, Malcolm gets great seats for him and Lois to see Lois' favorite singer. Lois then gets lucky and is invited backstage where all she really wants to do is figure out why Malcolm doesn't want her around.
Hal, on the other hand, is looking all across Las Vegas for a slot machine that he has had dreams of winning the jackpot on.
Francis is also in trouble when he gets behind on duties at the ranch, and for the first time sees that Otto isn't just a pushover for everything.
Malcolm is a regular high school kid trying to navigate his way through life despite the various obstacles thrown in his way a complete misunderstanding of girls, the constant burden of masterminding plans to get himself and his brothers into or out of trouble, and a miserable job at the Lucky Aide not to mention a severe case of teen angst.
Although Malcolm has a genius IQ, he can't seem to make sense of the opposite sex, much less his embarrassing family. Lois is the outspoken, opinionated mom, who still manages to rule the roost even though her boys are growing wise to her crafty ways. Hal, a dad who is just a bumbling, big kid at heart, often finds himself creating more chaos than his five boys combined.