Peter is accepted into Horizon High, a school for geniuses, where his best friend Harry Osborn was just suspended; Peter makes his debut as Spider-Man and must battle the Vulture.
The Scorpion is wreaking havoc at the museum and it is up to Spider-Man to stop him.
Norman Osborn creates the Osborn Academy for Geniuses as a way of saving his son Harry the embarrassment of being suspended from Horizon High.
As Peter tries to get through his normal life, he contends with Black Cat to recover the item she stole from Horizon High.
Harry returns to Horizon High, and Max decides to throw the first ever dance party. During the party, the Rhino is born and causes havoc for the students.
Spider-Man meets Sandman and helps him reunite with his estranged daughter with some assistance from the Venom symbiote.
Spider-Man uses his new black costume but it wants to destroy him.
Ghost hijacks the Stark Expo and Spider-Man must unleash the symbiote to save lives.
Miles Morales is bitten by an experimental spider and gains spider powers, so Spider-Man teaches him the responsibilities of being a superhero.
Kraven the Hunter does a live broadcast of his hunt for Spider-Man.
On Halloween night, Spider-Man must team up with the incredible Hulk to stop Man-Wolf, a super-strong gamma-powered werewolf, from infecting the rest of Manhattan.
Spidey must stop a low-level villain who has acquired some impressive freezing technology.
The symbiote has escaped the Avengers Compound and attached itself to a new host. Now Spidey must find out how to beat it and who the new person is underneath.
Spider-Man is targeted by a new costumed figure named Screwball for a series of online prank videos which block him from fighting crime.
When Otto Octavius is caught in an explosion that fuses his robot arms to his body, Spider-Man sees the opportunity to recruit "The Octopus" into becoming a hero.
Spidey invites The Octopus to patrol the streets alongside Miles and himself until it becomes clear that Otto isn't exactly a team player.
Peter spends a day at Oz Academy in the hopes of finding a clue that will convince Harry that his Dad is out to destroy Spider-Man.
Spider-Man must team up with Gwen Stacy and a reluctant Harry Osborn to investigate the truth behind the missing Raymond Warren aka the Jackal.
Spider-Man tracks a new villain with spider powers who steals his experimental stealth suit and threatens the entire city.
Everyone in Manhattan manifests spider powers; Spider-Man and Spider-Gwen must help Black Widow track down Crossbones before he delivers the vibranium to Arnim Zola and Hydra.
Peter must find a way to cure Gwen Stacy and Norman Osborn after they turn into spider monsters; things get harder when Kraven the Hunter turns New York into his hunting grounds.
Peter and Harry must battle through an island of spider monsters to get to Norman Osborn, who appears to control them all; the boys discover the real mastermind.
To cure the spider-monster population of Manhattan, Spider-Man must lead Kid Arachnid, Anya and Harry on a desperate, last-ditch effort to stop the Jackal.
Spider-Man takes on Doc Ock and his Sinister Five before they brainwash Spidey and destroy New York City.
Spider-Man must find a way to stop Hobgoblin, who seems completely bent on doing whatever it takes to destroy Spider-Man.