Ash and friends arrive in Driftveil City and immediately head to the gym. However, the gym leader, Clay, does not want to battle at the moment. With nothing else to do they decide to tour the city. They run into a motorcyclist named Charles who acts like their tour guide. Soon they witness a crime taking place and the town's hero, the Mighty Accelgaurd, save them. Ash becomes a fan of the hero and wants to meet him, which leads them to being in the middle of a villainous plot.
A young boy named Ash Ketchum embarks on a journey to become a "Pokemon Master" with his first Pokemon, Pikachu. Joining him on his travels are Brock, a girl-obsessed Rock Pokemon Trainer, and Misty, a tomboyish Water Pokemon Trainer who may have a crush on him. Ash and Co. end up traveling through various regions, including Kanto, the Orange Islands, and Johto, and then enter the Pokemon League competitions there.
Along the way, they run into many confrontations with Jessie, James, and Meowth, a trio of Pokemon thieves who are apart of an evil organization called "Team Rocket". But every time Team Rocket try to do their evil deeds, they fail thanks to Ash and his Pokemon.