Ash and the gang are at Lumiose airport. They all allow their Pokémon to say goodbye to each other. Dedenne runs off in frustration. After Bonnie convinces Dedenne to return, Serena's flight to the Hoenn region is about to take off. Serena heads to her flight and gives Ash a kiss before boarding her flight. With some time left before Ash's return flight to Kanto, he and Clemont have one last Pokémon battle. Ash announces his arrival at home in the Kanto region.
A young boy named Ash Ketchum embarks on a journey to become a "Pokemon Master" with his first Pokemon, Pikachu. Joining him on his travels are Brock, a girl-obsessed Rock Pokemon Trainer, and Misty, a tomboyish Water Pokemon Trainer who may have a crush on him. Ash and Co. end up traveling through various regions, including Kanto, the Orange Islands, and Johto, and then enter the Pokemon League competitions there.
Along the way, they run into many confrontations with Jessie, James, and Meowth, a trio of Pokemon thieves who are apart of an evil organization called "Team Rocket". But every time Team Rocket try to do their evil deeds, they fail thanks to Ash and his Pokemon.