After the breakup between Owen and Sam, The Newlys, Dena, and Andrea decide to pack it up and head out for an overdue family vacation to a lodge. Sam is met by an unexpected friend at the lodge, Brad, who was her childhood sweetheart. Things get turbulent when Andrea makes a pass at him.
Samantha "Sam" Newly is left in a coma for a week following a terrible accident. When she awakes, Sam has no memory of any past experiences or events and must start her life over.
However, Sam quickly discovers that instead of being a good-hearted person, she was self-centered, narcissistic, and failed to have any real relationships - a person that most people disliked. Now, faced with amnesia, Sam must try to right her wrongs and struggle with the desire to regress back to her old ways.
Starting over and drawing the line between good and evil proves harder than Sam ever thought.
Samantha Who? - The Family Vacation Synopsis and Schedule