After helping the League of Freedom save the world, Dr. Devizo and his team of villains move into the Mansion as bona fide heroes. The team struggles with their new roommates as Robobot travels across the country in search of the elusive Swine Kampf.
When Lex starts dating the vigilante anti-hero Max Penalizer, Titanium Rex and Dr. Devizo team up to break them up. As the villains of the mansion set their eyes on bedding Cooch, Robobot learns the dangers of telling humans little white lies.
Claudette, Cooch's former owner, returns with a lawyer seeking to get her cat back, so Robobot agrees to represent Rex in the upcoming trial; the Groaner tries to discern the true meaning behind Black Saturn's name.
Ivan Whiff returns to help the League refurnish their Mansion with items from his Swedish Furniture store. While Whiff tries to recruit Robobot onto his new team, Black Saturn tries to lure Bugula into a hero/nemesis relationship.
When Cooch's claims that Leprechauns are attacking Storm City turn out to be true, the League of Freedom is drawn into a battle with assorted mythical creatures. The injured Black Saturn recruits Courtney to join the fight in a mechanized suit.
To save former member Zenith, the League of Freedom travels to the Godsrealm to fight her evil Uncle Ridan; Robobot learns what it means to be a real boy as Rex must prove to be a hero true in order to wield the Sword of Azimuth.
Under an evil spell, The League of Freedom is transported to an apocalyptic future where American Ranger rules the U.S. under a dictatorship. While the heroes confront the horrors that await them in this future, they must help Robobot and Future Robobot fix the time machine needed to return home.
The League of Freedom returns to their home timeline only to discover they've been replaced by the new "League of Freedom West". When Titanium Rex sees that the new squad includes an improved clone of himself, his insecurities get the best of him and his villainous proclivities emerge.
When rival gangs of werewolves and vampires get caught in an eternal war that only Black Saturn can end, Courtney is inadvertently transformed into a vampire. Rex and Ranger are determined to steer Black Saturn away from the dark arts while Robobot steers Lex toward a mindful meditation practice.
Desperate for a comeback, Titanium Rex books an appearance for the team at a comic convention. In one of several humiliating experiences, he bumps into an old '90s version of The League, obsessed with pogs, roller blades and earning Rex's approval. Meanwhile, Lex is lured on a date.
The League of Freedom is enlisted for a top-secret mission on a perilous jungle island. Despite Cooch going feral and American Ranger succumbing to jungle paranoia, The League successfully identifies the island's supervillain. Elsewhere, Black Saturn desperately tries to prove himself a team leader.
An old, powerful foe from Dr. Devizo's past returns to haunt him... and aims to hug him swiftly afterward. Both The League of Freedom and The League of Freedom West risk their lives keeping him alive while Lex struggles with an internal conflict over her genetic makeup.