Four months have passed and Dean awakes to find himself in a pine box - he's been freed from Hell. He reunites with Sam and Bobby, but soon they all begin to wonder what pulled Dean out of Hell.
After Dean's encounter with Castiel, Dean, Sam and Bobby brush up on their biblical lore when they're attacked by the vengeful spirits of people from the Winchesters' past. They're warned it's a sign that someone is trying to break seals which will bring on the apocalypse.
Dean is shocked to discover he has been transported back in time to Lawrence, Kansas. But the shock is short-lived after running into a younger John Winchester and Mary who are in love.
Dean is unaware why he was sent back but is enjoying his time with his parents and new-found grandfather, who may be the key to Sam and Dean's predicament.
Sam and Dean learn Jack Montgomery is transforming into Rugaru, a flesh-eating monster. People infected are unaware as to what is going on until they turn into cannibals and begin to eat human beings. Sam tries to reason with Jack so that he will control his urges, but Dean refuses to believe that the urges can be subdued.
Sam and Dean look into a string of murders committed at Oktoberfest. The first victim is found with bite marks, leading them to believe they were caused by a vampire. However, the second victim appears to be killed by a werewolf. When a mummy rises from the crypt, Dean believes that a shape-shifting creature is behind the attacks.
Dean becomes the latest victim of a ghost sickness that causes the victims to steadily become more fearful until their hearts burst. With time running out, the brothers must figure out how to destroy the ghost responsible.
With Halloween quickly approaching, Sam and Dean must find a witch who is making human sacrifices in order to summon a demon. Meanwhile, Castiel returns with Uriel, an angel wanting to smite the entire town.
Want to score a hot girlfriend, win the lottery or have your favorite teddy bear come to life? Then plunk a coin in a small town's wishing well and stand back. One problem: The wishes come true with a twist.
Sam and Dean must team up with Ruby to find Anna, a girl who can listen in on angelic conversations... and who the demons want to acquire. Meanwhile, Sam fills Dean in on how he met Ruby during Dean's time in Hell.
"I'll Kill her gentle". The angels want Anna dead, so Sam and Dean go on the run with the frightened girl, determined to discover the secret that has set the furies of Heaven on her.
When the ghost of a young woman haunts an abandoned house, Sam and Dean investigate. However, the situation gets complicated when a family moves in and ignores the brothers' warnings.
Aging magician The Incredible Jay performs the dangerous Table of Death trick and emerges unscathed. Jay cheated the Grim Reaper, but one of his rivals didn't. He checked out while Jay was doing his act.
Fast times at Truman High. Murder brings Sam and Dean back to one of their old high schools, where they investigate possible demonic possession and take a few trips down memory lane.
In a small town in Iowa, three loving husbands hug their wives. Turns out these guys believe in spreading their love around: Each is spending plenty of the family income on strippers at a nearby nudie bar.
Reapers take a break from work, and that means no one can die. But the escorts to the next world aren't off getting some R&R, unless you call being held hostage by a demon restful and relaxing.
Can torture be God's work? After seven angels are mysteriously cuddled, Castiel and Uriel demand that Dean use the agony-inducing skills he learned in Hell to extract information from Alastair.
Sam and Dean both work at a ironworks company. Dean is in sales and marketing, Sam in tech support. They don't remember each other, or their lives as Hunters. However, when a ghost starts causing suicides among the employees, the brothers have to learn quickly who and what they are, or die trying.
Dean and Sam learn that they're the protagonists in a series of cult novels detailing the adventures of two intrepid supernatural hunters. They confront the author, only to discover that he's the prophet of the Lord... and he's writing the Winchester Gospels. Now Sam must deal with the writer's next prophecy: that he gives in to Lilith.
The guys are on the road when a call comes in on their dad's old cell phone. A college student named Adam Milligan says that his mother's disappeared and he's trying to get hold of his father: John Winchester.
Dean gets a message to meet with Castiel on important business, but he and Sam discover that Castiel has been recalled to Heaven and his human host body, Jimmy Novaks, has no memory of what happened or what Castiel knew. Unfortunately, the demon forces don't know that, and wouldn't care if they did, and will go to any lengths to get Jimmy for themselves.
Sam is plagued by horrendous nightmares and visions from his past as Bobby and Dean force him to go cold turkey to break his addiction to demon blood. Meanwhile, Castiel makes Dean a deal, and the demons break all but the last few Seals.
On the eve of the Apocalypse, Lilith plans to open the last seal and Dean and Sam find themselves on opposing sides. Zachariah reveals Heaven's intentions and Castiel must make a choice. And the nature of the last seal is revealed.