Heartbroken and disillusioned, junior doctor Ruby Walker ditches her life in the UK for a fresh start, but when she arrives at the Good Karma Hospital, nothing is quite what she expected - not least her eccentric new boss.
The full moon spells trouble when a mystery Adonis washes up on the shore. As the team race against the clock to treat a local snake catcher whose luck may finally have run out, tensions mount when new girl Ruby questions Gabriel's professional conduct.
As Holi festival fever hits the Good Karma Hospital, an abandoned baby strikes a personal chord with Ruby. Lydia is reacquainted with an ageing ex-pat artist, whose alternative life choices may be about to catch up with him.
On the day that he is attending a lavish Indian wedding, Ram clashes with Lydia when a medical case becomes personal. As Ruby treats a patient from the UK whose story does not quite add up, she is left questioning where she truly belongs.
Lydia and Ruby visit a convent to make a seemingly miraculous diagnosis. Then Lydia's interference in the destiny of a young nun backfires - bringing her to blows with Ruby. Maggie and Paul join local pilgrims trekking through the jungle - but is Maggie searching for her own miracle?
As the first monsoon rains arrive, tensions run high between Lydia and Ruby - leading Ruby to make a shock decision. Maggie's health is rapidly declining and her daughter Debbie insists on returning to the UK. Will Maggie be granted her dying wish to stay in India?.