Ryan is asked to watch his neighbor's dog, Wilfred, who looks like a dog to everyone else but appears as a man in a dog suit to Ryan. Ryan has also just attempted suicide before he is supposed to start a new job.
Ryan lies to Wilfred to do Jenna a favor and learns a disturbing secret about her in return. At the beach, Ryan is fined for taking dog Wilfred to the beach.
Ryan gets into trouble when his neighbor Spencer visits to give Ryan his wallet back and find the one responsible for the break in.
Wilfred has a shocking experience when Ryan leaves him at a doggy day care to reconcile with Kristen.
Wilfred reveals an extraordinary ability when Ryan takes him to a hospice to volunteer.
Wilfred asks for Ryan's help to break up Jenna and her boyfriend.
Love interests for both Ryan and Wilfred enter their lives.
When Wilfred learns that Ryan feels responsible for his childhood dog's death, he assists him in find out what happened back then.
Ryan's resentment of his mother even grows when she moves in and becomes friends with Wilfred.
Wilfred tries to find Ryan a human friend.
Ryan meets someone who questions Ryan's friendship to Wilfred.
Just as Ryan finds happiness in his life, Wilfred begs him to sacrifice it for a larger purpose.
A crisis arises when Ryan ignores Wilfred's advice.