After Charlie and Dee unknowingly eat some of Frank's human meat, the two develop an insatiable hunger for it. Meanwhile, Mac and Dennis get into sport hunting and go after what some might consider to be the most dangerous animal in the world.
To capitalize on the high gas prices, the guys invest in barrels of gasoline that they plan to sell door to door. Meanwhile, Dee and Frank resort to some drastic measures to stop Bruce Mathis from donating Barbara's money to a Muslim cultural center.
After Frank invests in a billboard, he and Mac attempt to find Paddy's next top model. Dennis enters the competition to prove that he has what it takes to be featured on the billboard. Meanwhile, Charlie and Dee work together to come up with the next big thing on Youtube.
Charlie wants Mac to beat up the Waitress's new boyfriend, but what he doesn't know is that his friend is the one who's seeing her. A hurt Dennis tries to convince Charlie that he is the true best friend after the title was bestowed to Mac.
Mac and Charlie fake their deaths to avoid the wrath of Mac's father who was released from prison and is out for vengeance.
Dennis, Frank, and Dee find unique ways of coping with the apparent loss of their friends.
With the help of Mac and Dennis, Frank and Charlie attempt to figure out who pooped in their bed. Dee leads Artemis and the Waitress on a ladies night out on the town.
A newspaper critic is kidnapped by the gang after he calls Paddy's pub the worst bar in Philadephia.
After discovering Dennis' erotic memoir, Mac and Frank attempt to make some money off of it. Meanwhile, Dee and Charlie decide to spend a day in each other's shoes.
After Dee suffers a heart attack, she and Dennis try to be healthier. To receive health insurance, Mac and Charlie enter the corporate workforce.
To get Paddy's pub labeled a historical landmark, the gang tells the Philadelphia Historical Society that their bar was responsible for cracking the Liberty Bell.
Hoping to make their own dreams come true, the gang sets out to give an unexpected family an extreme home makeover.
In the season finale, Charlie gets the gang to help him put together a rock opera based on his song "Nightman."