When their grandfather falls into a coma, Dee and Dennis are notified that have been given legal responsibility on whether or not to pull the plug.
While they wrestle with the decision, Frank's obsession that Pop-Pop is hiding Nazi treasure sends Charlie and Mac off to track down a painting Charlie kept of his years earlier.
With the garbage men of Philadelphia on strike, Frank concocts a plan to undercut the union and get the contract to collect the city's trash. But when The Gang's elaborate plan starts to fall apart, everyone will get their hands a little dirtier than expected.
Dennis and the gang crash Maureen's wedding to make certain he'll be able to sever all ties, only to discover a union much scarier than kissing cousins.
Charlie and Dee become romantically involved with two members of a wealthy family, which arouses jealousy in Mac, Dennis, and Frank.
The Gang gets Freudian as they step into the therapist's office to work through their mountain of issues, but when Dennis thinks he has everyone figured out, the shrink turns the tables on him and exposes the insanity in his unique brand of pop psychology.
Mac, Charlie and Dee struggle with their faith as Charlie's mom fights cancer. Meanwhile, Frank loses his memory amidst a search for buried treasure.
With Charlie under his wing, Frank cleans up so he can get his hands dirty and help out his old company with one last big merger. An unwritten rule of the bar gets the rest of the gang caught up in a case of mistaken identity.
After slipping into an unhealthy obsession with computer games, The Gang wrestles to define the difference between the real and the virtual worlds.
Every member of The Gang has something to celebrate at Guigino's, Philly's finest eatery, but when Mac and Dennis' private dinner is interrupted by an unexpected sighting of Frank and Charlie, the in-fighting begins. Dee also turns up at a table for one, and over the course of the night, the "one-ups-manship" soars to new heights.
Court is in session at Paddy's Pub as Frank and Dennis present their cases to the rest of the gang, resulting in a verdict that will change their lives FOREVER... but not really.