When Coulson and the team discover a new Inhuman, S.H.I.E.L.D. comes face to face with another organization searching for powered people. And still reeling from Simmons' dramatic disappearance, Fitz goes to extreme lengths to try to learn how to get her back.
Fitz and the team enlist the aid of an Asgardian to unlock the secrets of the ancient monolith that swallowed Simmons, and Agent May is at a crossroads in her personal and professional life.
Daisy, Mack and Coulson race to protect Lincoln as Rosalind's team hunts down the Inhuman in their quest for powered people. Meanwhile, Hunter proves that there is no line that he will not cross to exact his revenge against Ward and Hydra.
Having reluctantly agreed to share information with Rosalind and the ATCU, Coulson and the team search for the Inhuman who is killing other Inhumans; May feels that Hunter's mission to take down Ward is getting too personal.
After her dramatic rescue from another planet, Simmons is still reeling from her ordeal and reveals how she had to fight for her life in a harsh new world.
The stakes get even higher as Hunter and May continue to go after Ward and Hydra, and Daisy and Coulson begin to suspect that the ATCU may be keeping a big secret from S.H.I.E.L.D.
As Daisy and the team fight to protect Inhumans, S.H.I.E.L.D. discovers the shocking truth about one of their biggest foes. Meanwhile, Fitz helps Simmons recover information that could lead them back through the portal.
The S.H.I.E.L.D. team discovers dangerous truths about the ATCU, and Ward's plans to destroy S.H.I.E.L.D. take a surprising twist.
Ward's campaign for revenge brings the S.H.I.E.L.D. team to their knees, and Coulson proves he will do anything to settle the score.
S.H.I.E.L.D. and Hydra go head-to-head in a battle that will change Coulson's world forever. While Daisy and her team of Inhumans fight to keep Hydra at bay, Coulson and Fitz take the ultimate risk.
In the aftermath of his trip to Maveth, Coulson is more determined than ever to get to Gideon Malick and put an end to Hydra once and for all. Daisy and the team encounter more Inhumans who have powers like they've never seen before, but will they be friends or enemies of S.H.I.E.L.D.?.
Coulson and General Talbot are forced to team up and attend a worldwide symposium on Inhumans, where they suspect Malick has an inside man. As the S.H.I.E.L.D. team gets closer to the truth, an unexpected traitor is revealed.
Bobbi and Lance follow Gideon to Russia, and discover that he and a secret Inhuman are planning a coup. To stop them, the couple must make the ultimate sacrifice for the good of S.H.I.E.L.D.
Mack hopes for some downtime with his brother Ruben, but his plans are interrupted when a militia group calling themselves the Watchdogs prepares to wipe out the Inhumans... and a ATCU facility is their first target.
Due to an Inhuman's power, Daisy gets a glimpse of the a future and tries to change what Fitz and Jemma insist can't be changed. Meanwhile, Hive has Gideon initiate the first phase of his plans for Hydra.
While Daisy and Lincoln hunt down a former Afterlife resident who knows more about Hive, Coulson and his team investigate Hydra's most recent purchase of an agricultural corporation.
Agent Daisy Johnson brings the Secret Warriors together for a mission that will affect them all; knowledge of Hive's powers has S.H.I.E.L.D. mistrusting everyone.
The S.H.I.E.L.D. team is left reeling and decimated as Hive continues to sway Inhumans to his side. But there is a sliver of hope as Agents Fitz and Simmons follow a lead that may be able to stop the maniacal Inhuman once and for all.
Coulson and his team race to combat Hive's control over the Inhumans, as their enemy's deadly plan for the human race is revealed.
In the aftermath of the events of Captain America: Civil War, S.H.I.E.L.D. feels pressure to reveal their involvement with Inhumans. But with the stakes higher than ever and Hive growing stronger, the team is tested in ways they could never anticipate.
The team tries to stop Hive's missile launch, and succeed in capturing the Inhuman. However, they discover that Hive anticipated them and soon they face an enemy from within.
The team learns what Hive's master plan is, and realize that one of them must die if they hope to stop it.