In light of the Sokovia Accords, and with Hydra obliterated, S.H.I.E.L.D. has been legitimatized again and no longer needs to operate in the shadows. Since the world presumes that Coulson is dead, the organization needed a new Director to be the face of the organization. Coulson finds himself back in the role as an agent and teamed with Mack, and together they are tasked with tracking down and confirming the presence of Enhanced people, aka Inhumans. Agent May is tasked with training specialist strike teams, and Fitz and Simmons have taken a big step forward in their relationship.
Following Coulson's stepping down as Director, Jeffrey Mace is made the new Director of S.H.I.E.L.D. and it's public face. Daisy meets with Robbie at his place of work, saying she knows about his history but is surprised to find he isn't Inhuman like her. May's exposure from the specter last episode gets out of hand where Mace, revealing he's a super strong Inhuman, knocks her out and sends her to an undisclosed location. Mack & Fitz investigate the specter and encounter Ghost Rider. Meanwhile, the specter who infected May releases her compatriots who were in similar containers for years due to using the "Darkhold".
Coulson, Mack and Fitz try to locate and neutralize a rogue group looking to stop Inhuman Registration worldwide; Simmons and Dr. Radcliffe have only a short time to save May before she succumbs to her illness.
As Ghost Rider's quest for vengeance brings him into an explosive confrontation with S.H.I.E.L.D., Coulson and Mack must rely on an unlikely ally in their time of desperate need; and Daisy reunites with a familiar face to stop the Watchdogs.
As Robbie Reyes struggles to control The Ghost Rider, S.H.I.E.L.D. infiltrates a high-security prison to unravel the secrets that haunt them all.
The shocking origin story of Robbie's transition into Ghost Rider is revealed as the lives of Coulson and the team hang in the balance.
After losing half their team, the remaining members look for answers as time begins to run out for Ghost Rider.
S.H.I.E.L.D. and Ghost Rider find themselves unlikely allies when the lives of all of Los Angeles hang in the balance.
Coulson is unaware of a dark secret May is hiding, even as the two grow closer; Aida is determined to find the Darkhold.
Coulson and Mack discover a shocking secret about Mace, which leaves all of S.H.I.E.L.D. in a dangerous position.
May races to find the truth about what happened to her, while Aida's next move could mean the death of them all.
Agents Sam and Billy Koenig are hunted down to get at the Darkhold book, and only Coulson and the team can save them before the clock ticks out.
Daisy, Mace and the S.H.I.E.L.D. team must find a way to contain an explosive Inhuman. Meanwhile, Coulson and Mack come face-to-face with Radcliffe's inspiration for Aida.
Mace fights for his life while Coulson and team find themselves in a deadly cat-and-mouse game as they attempt his rescue.
As more LMDs infiltrate S.H.I.E.L.D., suspicion begins to turn to paranoia among the members of Coulson's team.
Hail the New World Order! Daisy and Simmons are the only hope to save everyone in a world controlled by Hydra.
As Daisy and Simmons struggle to discover an escape route to the real world, the identity of the Inhuman leader of the Resistance is revealed.
The truth behind Fitz's turn could bring down all of S.H.I.E.L.D.
Daisy finds herself teamed up with an unlikely partner. Meanwhile, Aida prepares to put her ultimate end game into effect.
Daisy and Simmons race against the clock to get the team out of the Framework, but not everyone is ready to leave.
Coulson and the team's victory in the Framework is short-lived, revealing an even deadlier enemy looming against them all.
With the surprising emergence of Ghost Rider, Coulson and the team attempt to stop Aida from ending the world.