Following Coulson's stepping down as Director, Jeffrey Mace is made the new Director of S.H.I.E.L.D. and it's public face. Daisy meets with Robbie at his place of work, saying she knows about his history but is surprised to find he isn't Inhuman like her. May's exposure from the specter last episode gets out of hand where Mace, revealing he's a super strong Inhuman, knocks her out and sends her to an undisclosed location. Mack & Fitz investigate the specter and encounter Ghost Rider. Meanwhile, the specter who infected May releases her compatriots who were in similar containers for years due to using the "Darkhold".
Season 4 Episode 2 of Marvel's Agents of S.H.I.E.L.D. was watched by 2,950,000 viewers, resulting in a 0.90 rating in the 18-49 demographic.
After surviving events on the Helicarrier, S.H.I.E.L.D. Agent Phil Coulson puts together a small team of S.H.I.E.L.D. agents to handle strange new cases. They investigate Project Centipede, eventually uncovering that Centipede is backed by the organization Hydra, which has infiltrated S.H.I.E.L.D.
Following the destruction of S.H.I.E.L.D., Coulson and his team look to restore trust from the government and public while dealing with Hydra and the newly revealed Inhumans, people who possess special abilities. Coulson's work is further complicated by the appearance of another faction of S.H.I.E.L.D. agents who do not trust his leadership.
Coulson begins a secret mission to assemble a team of Inhumans to deal with new threats to the world, while Hydra returns its ancient banished Inhuman leader to Earth.