Jackie's back to using again, but she's doing it differently this time: maintaining a clean and sober cover, going to 12-step meetings - even finding herself a sponsor - all the while getting her drugs from the towel girl at the gym. Meanwhile at All Saints, Zoey finds out that everyone knows about her 'secret' relationship with Prentiss. Season premiere.
Jackie steals Dr. Roman's DEA number. Coop is recruited by a 'sperm scout'.
Coop gets the crushing news that his sperm count is too low to allow him to donate. Carrie gets a lucky break, which leads to a medical segment on the local news. Akalitus is on a winning streak, too, with her poker habit starting to pay off. Jackie, however, gets blindsided when Grace - who's been arrested for shoplifting - drops a bomb.
Jackie goes off the deep end when she witnesses the budding relationship between Kevin's fiancé, Mia, and Grace. Frank discloses a secret about his past - giving Jackie all the ammo she needs to keep him at bay. Meanwhile, back at All Saints, Akalitus' poker streak continues, Coop and Carrie's bond deepens when she decides to put him on television, and Prentiss gets a visitor from his past.
Frank searches Jackie's house for drugs, but she removes them in time and hides her stash in a ladies room at the hospital. Later, Jackie bonds with a homeless, alcoholic nun; and finds comfort in the arms of a fellow drug user. Meanwhile, Zoey confronts Prentiss about his dissatisfaction and encourages him to do what he loves.
Jackie's fake identity is compromised - but she's got more pressing problems to deal with: she's on her last bag of pills, Frank has just moved in, and her sponsor Antoinette is hounding her about her sobriety. Meanwhile, Prentiss plans a big night out with Zoey, but their date is cut short when she suspects that something is wrong.
Jackie is ambushed by Antoinette. Coop's dream finally comes true.
Jackie detoxes at home - with help. Frank raises an objection about Grace.
Jackie learns about a DEA investigation at the hospital that will require her to take a urine test, so she plots to get around it. Meanwhile, Kevin and Mia plan their wedding; the homeless nun returns in worse shape than ever; and Coop and Carrie find a way to skirt their no sex in the hospital rule.
Jackie and Frank breakup. Jackie realizes the only way she can continue to use drugs is by separating herself, from those closest to her. Carrie forgets Coop's 40th birthday. Zoey decides that she wants to be a nurse practitioner. The DEA's investigation continues.
Jackie heads to Kevin's wedding, reluctantly. Zoey witnesses Jackie nearly make a fatal error with a patient, at work. Carrie wants to meet Coop's mom. Akalitus feels pressured by the DEA.
Akalitus tells Jackie she has to admit that she's on drugs, or will have to take a test. Coop confronts Jackie, but she has surprising news for him.