In the series premiere, veteran ER nurse Jackie Peyton bends the rules to create something good from a patient's senseless death, while concealing her addiction to a pain hugger she gets from her secret boyfriend, hospital pharmacist Eddie.
Jackie and her husband Kevin are worried that their daughter Grace might have an anxiety disorder. Meanwhile, Jackie's Percocet-laced coffee gets into the wrong hands.
Jackie meets a patient who uses his wife's chicken soup to treat his heart disease. Later, she talks to Dr. O'Hara about her daughter's anxiety and learns that a pill-dispensing machine will take Eddie's job.
Jackie and Kevin think about sending their daughter Grace to a private school. Meanwhile, stoic Dr. O'Hara can't escape a boy who wants to thank her for saving his twin brother's life.
A 10-year-old girl needs Jackie's help to care for her mother who suffers from lupus. Furthermore, Mrs. Akalitus manages to taser herself.
When Jackie meets an old friend and fellow nurse who suffers from terminal lung cancer, she is asked to help her commit suicide. A gall bladder attack brings Dr. Cooper's mother to the hospital where she gives away a secret about her son.
After the ex-husband of his date attacked him with a knife, a man is brought to the ER. Meanwhile, Mrs. Akalitus takes care of a foundling who was left at the nurses' station.
When Jackie addresses a temp nurse's drug abuse, he calls her an hypocrite. In the meantime, Mrs. Akalitus is still responsible for the baby left at the station.
Jackie has to deal with the consequences of her drug abuse and Zoey's criticism on Jackie's initial treatment of a patient. Also, Jackie falsifies an organ donor's file.
Jackie has to come up with drastic measures to keep Dr. Cooper from exposing her for falsifying an organ donor's file. Besides, Jackie can't take her wedding ring off when she is about to meet Eddie and seeks Dr. O'Hara's help.
Jackie gets cut off her Percocet supply when Eddie is finally replaced by a pill-dispensing machine. Meanwhile, Zoey makes a mistake and gives a wrong dosis of a painhugger and Mrs. Akalitus has to deal with the parents of her foundling.
Kevin and Jackie meet for a rendezvous at midnight. In the meantime, Jackie's family is no longer a secret to Eddie and Dr. O'Hara's mother is brought to the ER.