Jordan and Drew perform a daring rescue by jumping from a chopper. Landing at the nearest VA hospital, Jordan sparks a plan to appease Julian and reunite her night shift team. Back at the hospital, Paul deals with the repercussions of standing up to his father while Scott dives headlong into his professional life. Kenny butts heads with Cain, a traveling nurse with a mysterious past. Shannon indoctrinates Cain as they work in San Antonio Memorial's understaffed and overworked ER. Meanwhile, TC is held captive in Syria. In order to find Syd TC must treat his captor instead of returning to the safety of an air base with a civilian volunteer, Amira.
An amusement-park disaster results in mass-casualty victims flooding the hospital. Also, TC continues his quest to reunite with Syd; Drew reevaluates his priorities as a new father; Jordan tries to get Paul back on staff; Scott pursues a more active role in the hospital.
Jordan and Cain travel to the scene of an oil-field explosion and treat a patient with extreme injuries. Also, Drew and Paul try to save a patient's severed hand; Scott encounters a person from his past; and TC tries to help a sick Syrian child.
A patient from a distant town arrives for surgery. Meanwhile, Jordan gets creative to help a veteran in need; Drew struggles with being a working parent; Kenny learns to not worry about trivial matters; and TC joins in a daring rescue mission in Syria.
Drew faces an emergency on his flight home when passengers become sickened. Also, some staffers participate in an obstacle-course fund-raiser hosted by Akbar Gbajabiamila; Scott has an unforgettable date; TC treats a soldier.
Kenny joins Drew at his MMA veteran's support group and finds himself in the fight of his life. Jordan and Cain treat casualties from a hotel fire while Shannon follows a hunch to help save a young victim. Paul's superstar sister, Dr. Bella Cummings, pays a visit to San Antonio Memorial and provides desperately needed support during a busy shift. Meanwhile, TC finally returns home, forcing him to deal with Topher's death.
When protestors descend on a funeral for a dear member of the night shift family, multiple veterans are injured and brought to San Antonio Memorial for treatment. A high profile politician from Drew's past triggers flashbacks to his time in Iraq. Jordan, Scott, and TC disagree on how to best provide care for the politician. Paul and Shannon must improvise while tending to Doug, a former POW. Cain and Drew treat a fearless photographer.
When Jordan realizes the hospital is under cyber-attack, she leads the team in managing patient care as chaos ensues. Drew and Kenny treat a critical patient forcing Drew to call on his medical and military training. TC joins Rick and his partner on a SWAT drug raid. Meanwhile, he wrestles with whether or not he should return to Syria to tie up loose ends.
TC and Jordan accompany a SWAT team on a raid and wind up with an emergency room full of sickened immigrants, including one with murderous intentions. Scott pulls a dream team together to impress the Colonel in charge of setting up a combat training program. More is learned about Cain's past. Kenny shares some big news with the group, while Shannon keeps something personal from Paul.
A shooting at a nearby college sends TC, Jordan, Drew and Amira into the field, where they assist Rick with a deadly situation. Scott implements a new training program and locks horns with Julian. Drew struggles with frustrations about going to Army Ranger School while Shannon and TC both contemplate their future at San Antonio Memorial.