Spider-Man and Nova must help the Guardians of the Galaxy face a threat that has followed them to Earth.
Spider-Man's dream of joining the Avengers becomes a nightmare when Loki switches bodies with the web-slinger, turning his new teammates against him.
Spider-Man and his friends team up with the Avengers to stop Loki and Doctor Octopus from destroying New York City with an army of Venomized monsters.
Spider-Man must team up with the super hero wanna-be Flash Thompson, when the Beetle wants them both destroyed.
To make matters worse, Flash had once again been Venomized but insists he's fighting for good.
Spider-Man wants to recruit Cloak and Dagger as new warriors for his S.H.I.E.L.D. team.
However, things don't go as planned when they must help Doctor Strange battle Dormammu.
Peter Parker's intellectual rival, Amadeus Cho, obtains Tony Stark's Iron Spider armor.
At Nick Fury's request, Spidey must recruit the new Iron Spider however, Taskmaster attempts to seize the armor for himself.
Spider-Man encounters The Vulture. A mysterious thief whose memory loss sends him to Doc Oc for answers.
Spider-Man enlists the help of one of the X-Men, Wolverine, on his trip to the Savage Land to help track down Ka-Zar and put an end to his plot, but they have more on their hands when they uncover Taskmasker and Kraven have their own plans.
The cast of "Jessie" gets animated in this special crossover episode that finds the Manhattan nanny in possession of a medieval sword coveted by the infamous Morgan Le Fey. Jessie and Spider-Man team up to save Halloween and the world from Le Fay's evil plans.
The new team of teenage heroes put together by Spider-Man is given their first test when the Taskmaster puts the plan he has been working on into action, testing them to see if they can work as a team or falter in their first challenge.
Spider-Man sees what the world would be like without him when Nightmare takes him on a journey through his past, present, and future.
Spider-Man finally ends up in his own universe, he finds Green Goblin has injected himself with the Spider-Men DNA from all the universes to become the Spider-Goblin. With Electro's help from the Siege Perilous he summons all the Spider-Men dubbed Web-Warriors and defeats the Spider-Goblin, but Electro turns on them and uses the Helicarrier to self-destruct and take out New York but is stopped with the help of Spider-Ham and Spider-Girl.
Spider-Man continues to pursue Goblin on a chase through parallel dimensions. First, he teams up with a Spider-Man from a noir world, and then he has a zany adventure with Spider-Ham.
Spider-Man chases Goblin through a portal to Medieval York, where he meets Spyder-Knight, and then to a parallel universe where Peter Parker has died and 13-year-old Miles Morales is now Spider-Man.
When the Goblin uses DNA from six alternative Spider-Men to grow his own powers, the original Spider-Man will need to assemble his alternative world counterparts to defeat him.
Spider-Man's education at the Academy begins, but it might be cut seriously short when a long-dormant villain wakes from hibernation and sets out to destroy S.H.I.E.L.D.
Spidey and Hulk are the last line of defense when a bitter rivalry between Agent Venom and Rhino threatens to destroy New York City.
Spider-Man and Ant-Man must shrink down to miniature size in a special submarine to rid Nick Fury's body of nanobots implanted by Doc Ock.
Craving Mexican food Spider-Man, Power Man and Squirrel Girl sneak out after hours for late-night burritos. Along the way they must contend with some of Spidey's enemies.
Spider-Man is the only one prepared to support Triton of the Inhumans as he returns to his home city to stop his people attacking and save New York from a war between S.H.I.E.L.D. and the Inhumans.
Spidey's fellow superheroes have been replaced by synthetic replicants by the evil Dr. Zola. Who can Spidey trust to help save the S.H.I.E.L.D. Academy?
While freeing classmates Spider-Man is captured by Arnim Zola and absorbed into his body. The freed friends must fight Zola to help Spider-Man escape the madman.
In this first of a four part story, Spider-Man, the Avengers and the Agents of S.M.A.S.H. battle their greatest foes for the fate of the planet. In the first round Spider-Man is chosen to be part of The Collector's team and is partnered with Hulk and Iron Man against The Grandmaster's team of villains consisting of Kraven, Molten Man and The Wendigo King.
In this second of a four-part story, Spider-Man, the Avengers and the Agents of S.M.A.S.H. battle their greatest foes for the fate of the planet. Spider-Man is partnered with Captain America, Red Hulk and Iron Fist in a game of capture the flag against Sandman, Blastaar and Ymir. Then Spider-Man is partnered with Power Man, Black Widow and Skaar against Doctor Octopus, Absorbing Man and Zzzax in a game of last team standing but things become a problem when the Grandmaster starts changing the environment of the game.
In this third of a four-part story, Spider-Man, the Avengers and the Agents of S.M.A.S.H. battle their greatest foes for the fate of the planet. Spider-Man teams up with Iron Spider, Agent Venom and Thor against Terrax, Attuma and Annihilus. Then Spider-Man uses LMDs to distract The Grandmaster so he, Iron Spider and Agent Venom can board Grandmasters ship to save the hostages. Can his plan succeed?
In this final part of a four-part story, Spider-Man, the Avengers and the Agents of S.M.A.S.H. battle their greatest foes for the fate of the planet. The Grandmaster has won the Contest of Champions, but Spidey asks for a winner take all rematch, can Spider-Man win?