Jane feels guilty that she isn't around for Mateo as much as she would like, so she decides to run for Room Mom against none other than perfect mom, Petra. With the help of Jane and Xo, Alba tries to impress her crush. Rafael tries to be there for both Jane and Petra. Meanwhile, Rogelio tries to slyly get information from Mateo about Xo and Bruce's relationship.
Set in Miami, the series details the surprising and unforeseen events that take place in the life of Jane Villanueva, a hard-working, religious young Latina woman whose family tradition and a vow to save her virginity until her marriage to a detective is shattered when a doctor accidentally artificially inseminates her by mistake during a checkup. And to make matters worse, the biological donor is a married man, a former playboy and cancer survivor who is not only the new owner of the hotel where Jane works, but was also her former teenage crush.