The Guardians must work together to escape the elaborate prisons created for them by The Collector.
The Guardians meet up with Spider-Man in New York City to defeat Thanos' super-powered symbiote.
The Guardians team up with Spider-Man to battle Thanos, who has harnessed the power of the Carnage Symbiote to become the ultimate weapon.
The Guardians run into trouble when they attempt to transport the notorious criminal, Thanos, across the galaxy.
The Guardians chase Thanos and Sam Alexander to Thanos' home planet of Titan, where they discover a gladiatorial arena featuring Jesse Alexander - Nova's father.
As the Guardians of the Galaxy get everything they want after handing Thanos over to the Nova Corps, Rocket Raccoon goes looking for a bounty. He competes with Wraith in capturing alien con artist Ichthyo Pike. Meanwhile, Groot looks for Rocket Raccoon where two criminals rob him and dump his body on a desert planet. He is found by it's inhabitants who use him as a scarecrow to protect their water and crops from a group of Gerboids.
At the Morag Temple, Gamora finds Nebula there and brings her along in atoning for the damages she has caused to other planets by giving them units which would also have them chased by it's inhabitants. Unfortunately for them, Yondu and Kraglin lead the Ravages into raiding the same planets in order to steal the units given to them. Now Gamora and Nebula must work together to reclaim each of the units and defeat the Ravagers.
Drax decides he no longer wants to be a Destroyer and looks into new occupations.
Quill starts his own talk show after beating Thanos! But to his dismay, everyone seems to hate it, especially the Grandmaster who is rigging the segments to destroy Quill.
The Guardians squander their riches and take on a simple transport job. It turns out that they are stealing from the Kree, and Phyla the Accuser will do anything to get it back!.
The Guardians find themselves in prison for stealing a mysterious package from the Kree - but it was all a set up by Howard the Duck.
The Guardians track down Howard the Duck to find out who set them up and why, but they don't get far before Phyla the Accuser catches up to them to deliver some Kree justice.
Phyla-Vell reluctantly teams up with the Guardians to bring The Collector to justice for destroying her home planet.
When the Guardians become separated in the Black Vortex, Gamora wakes up in a children's fairy tale, while Drax is trapped in a comic book. (Part One).
While caught in a CG sinister packing factory, Rocket must search for his best friend Groot and escape. (Part Two).
Quill finds himself in a claymation world where the Milano is flying into the sun, threatening to melt him. Meanwhile, Groot and Drax must fight Ronan in a Golden Age world. (Part Three).
Gamora and Quill battle their way through an 8-bit Super Marvel World. (Part Four).
The Guardians finally make it out of the Black Vortex, only to find that the galaxy has been taken over by sinister robots called the Darkhawks, who are disguised as their friends.
The Guardians don't know who to trust as the Darkhawks seem to have duplicated everyone, including Quill!.
The Guardians have to team up with Loki in Asgard when The Serpent infects the World Tree and threatens to destroy the universe.
As the Guardians prepare to take the fight to The Serpent, they Bifrost around the galaxy to gather reinforcements.
The Guardians and their friends search for the fragments of Dragonfang, a legendary weapon that will finally be able to defeat The Serpent forever.
The Guardians, Loki and Iron Man travel to the castle of the evil Hela to ask her help in fighting The Serpent.
With the Nova Corps defeated and the fate of the entire universe in jeopardy, the Guardians must turn to an unlikely ally to stop The Serpent.