Red presents the Task Force with a Blacklist case searching for a plastic surgeon who creates new identities for wanted criminals. Liz and her sister, Jennifer, secretly investigate the events that took place the night the real Raymond Reddington died.
While Liz and the Task Force track a notorious underground biohacker, Red initiates a strategy to extricate himself from a problematic position. Meanwhile, Cooper's integrity is tested with a difficult choice.
Red acclimates to his new surroundings in federal prison, where he is challenged by an old rival. Samar goes undercover to stop a black market organization that fronts cash to criminals. Liz and Jennifer continue their investigation into Red's past.