Team Venture must continue on without Brock, as they acquire a new bodyguard and Dr. Venture becomes involved in a plan to clone Hitler. Meanwhile, Brock must seek out his own destiny and get revenge against Hunter Gathers and Molotov Cocktease.
The Monarch kidnaps Hank and Dean, and demands a million ransom from Dr. Venture for the return of his boys. However, the heroic Captain Sunshine saves Hank and takes him to his Sanctum Solarium, where he has plans to bring the boy along as his new partner, Wonder Boy.
Rusty decides it's time to bring Dean along as a scientist, and exposes him to progressive rock music as an inspiration. Meanwhile, a rogue Dean clone is at large in the compound, and Dermott and a grounded Hank decided to have some fun.
Henchman 21 vows to find the hugger(s) of Henchman 24... and starts with the Venture Brothers. Meanwhile, the Monarch has an allergic reaction and Sgt. Hatred visits his old home.
The Phantom Limb takes on a new identity and attacks the Guild, while Sgt. Hatred and Hank bond over during their efforts to defend the Venture Compound.
Sgt. Hatred takes the boys to the movies, only to have a relapse after he discovers himself surrounded by young boys and out of his medication. Meanwhile, Dr. Venture goes into therapy with other former boy adventurers, but they soon have a crime to solve when their psychiatrist is cuddled.
The Order of the Triad must track down the Outrider, Dr. Orpheus' former apprentice who abducted the good doctor's wife. Meanwhile, Triana finds the portal in her bedroom, and Hank gives Dean dating tips.
While the Monarch schemes to dispose of Dr. Venture once and for all, Henchman 21 seeks revenge on Brock for the death of 24.
Brock, Hank, and Dean must go on a fantastic voyage into Rusty's brain to find out why he's in a coma. Meanwhile, Henchman 21 demands new henchsuits, but the Monarch is too busy obsessing with his latest purchase, a butter-glider.
Hank and Dean "graduate" from their learning beds, and wonder what to do with their lives. Meanwhile, Phantom Limb escapes the Guild and goes to Professor Impossible in the hopes of recreating the accident that gave him his phantom powers.
Someone is capturing heroes and villains and taking them to a super death camp. The forces of good and evil must join forces to stop their mysterious captor.
Hank opens a detective agency and enters a dark world of sinister crime and shady women.
Dean ends up interning with Professor Impossible, and discovers that his new employer is a member of the Revenge Society.
Dr. Venture is contemplating suicide, but Dr. Orpheus realizes that he's possessed.
The mysterious Investors come to make their claim on Billy's soul. Meanwhile, Pete White convinces SPHINX to look for his friend and then takes refuge at the Venture safe room.
It's prom night for the Ventures when Rusty has his friends hold a home-school celebration. However, Henchman 21, the Monarch, and Molotov Cocktease are crashing the party.