Regina's old enemy is in a dance competition, and Regina desperately wants to beat her, but she needs Sam's help. There's only one problem, the new Sam has two left feet, unlike the old Sam who could dance. Meanwhile, Todd weasels his way back into Sam's apartment, just as she was looking to start her new independent life.
Sam chickens out of going to Africia, when she finds out what all is required to go. She won't tell her family though, because from the start, they said she chicken out. Instead she is hides away with Dena and Andrea to make appear she is gone.
Desperate to regain her memory, Sam opts to join a clinical trial and starts taking pills for her memory. Sam's memories start coming back, but she doesn't like what she learns about her former self. Elsewhere, someone confuses Dena and Andrea as being a gay couple, which frustrates Andrea and sends her on the hunt to find someone hotter than Dena.
Sam and Andrea open up a real estate business. Sam wants to do things fairly, but her first client could change her mind. In an attempt to gain a basketball player's phone number, Andrea flirts with Todd's friend, Seth.
After being given community service for her altercation with a cop, Sam tries to help out Natalie, a wayward young woman, despite pleas from her friends not to. Howard tries to give Todd advice on how to win Sam back, even though he told Howard he wasn't interested anymore.
Sam breaks the news to Owen, that Todd is not only her roommate, but also her ex-boyfriend. Owen is understanding because his ex-girlfriend, Willow, lives with him as well. Ironically, Todd and Willow know each other from high school.
Sam and Owen head over to Regina and Howard's for dinner. Everything is going fine until Owen starts in on the horror of chicken farms, not knowing that Howard owns one. Dena oversteps her boundaries, when she undermines Chapman's authority with his employees. Todd enjoys the apartment alone after not telling Sam his mother isn't coming after all.
Sam tries to make herself appear to be an environmentalist, so Owen might like her more. Andrea doesn't fare well when the basketball player, Tony Dane, is looking for a date.
After the breakup between Owen and Sam, The Newlys, Dena, and Andrea decide to pack it up and head out for an overdue family vacation to a lodge. Sam is met by an unexpected friend at the lodge, Brad, who was her childhood sweetheart. Things get turbulent when Andrea makes a pass at him.
Andrea has a new boyfriend and Sam wants the couple to actually go on a real date for once. Todd doesn't like being just the roommate. Dena has a new penpal in Iraq, but she wonders if it means she's cheating on Chase.
Sam wants a baby, but she settles for a babysitting one of Dena's dogs to see if you has any motherly instincts. Howard and Regina inherit a plane, which causes Regina to take flying lessons.
Sam tries to become friends with Frank, once she thinks her old self was a racist. Andrea doesn't want to lose all the glamour of dating a celebrity, after Tony is outed as being gay.
Sam runs into financial troubles with at the craps table in Vegas with her parents. Could her old boss, Winston Funk, be just the person she needs to help her out of her jam? Andrea pulls a fast one on Dena after she reluctantly agrees to help improve Andrea's image in the media.
Sam dates a rock star to whom Dena and Andrea take a liking. Their unruly behavior toward Sam's new beau causes Sam to inch farther and farther away from her friends.
Thinking she already ruined one job for him, Sam tries to secretly help Todd out by distracting the competition up for the same job as Todd. Unbeknownst to Dena, Regina tries to sell Dena's house, so that she can still work with Sam.
Sam discovers that a family heirloom is the reason why her mom was in a feud with her sister and a mother, that Sam didn't know she had. Andrea is viewed as a jinx to Tony's team, after they start losing when she is there.
Sam becomes the head of the charity foundation for Winston Funk and hires Andrea as her vice president of legal affairs. She soon regrets this idea when Andrea shirks her duties in favor of planning her wedding.
Sam decides to give Todd a second chance by going out with him on another "first date", but Todd doesn't trust Winston Funk, believing he and Sam may continue the affair they were having before the accident. Meanwhile, Andrea appears on a reality TV series about celebrity weddings, along with her gay basketball star Tony Dane.
Samantha vaguely remembers something about Winston Funk's ex wife Gigi before the accident. Chapman tries to ask Dena to marry him. Andrea tries to lure Tony Dane into bed. Regina is caught in a love triangle as she prepares to leave on vacation with Howard.
It's Andrea's wedding day! While Andrea has chosen her life partner, Samantha has to make a decision as to who she wants to be with. Will it be debonaire millionaire Winston Funk or her not-rich-but-ever-reliable ex-boyfriend Todd. Even Sam's parents are at a crossroad as Regina and Howard begin to take separate paths.