Sam decides to give Todd a second chance by going out with him on another "first date", but Todd doesn't trust Winston Funk, believing he and Sam may continue the affair they were having before the accident. Meanwhile, Andrea appears on a reality TV series about celebrity weddings, along with her gay basketball star Tony Dane.
Samantha "Sam" Newly is left in a coma for a week following a terrible accident. When she awakes, Sam has no memory of any past experiences or events and must start her life over.
However, Sam quickly discovers that instead of being a good-hearted person, she was self-centered, narcissistic, and failed to have any real relationships - a person that most people disliked. Now, faced with amnesia, Sam must try to right her wrongs and struggle with the desire to regress back to her old ways.
Starting over and drawing the line between good and evil proves harder than Sam ever thought.