Desperate to regain her memory, Sam opts to join a clinical trial and starts taking pills for her memory. Sam's memories start coming back, but she doesn't like what she learns about her former self. Elsewhere, someone confuses Dena and Andrea as being a gay couple, which frustrates Andrea and sends her on the hunt to find someone hotter than Dena.
Samantha "Sam" Newly is left in a coma for a week following a terrible accident. When she awakes, Sam has no memory of any past experiences or events and must start her life over.
However, Sam quickly discovers that instead of being a good-hearted person, she was self-centered, narcissistic, and failed to have any real relationships - a person that most people disliked. Now, faced with amnesia, Sam must try to right her wrongs and struggle with the desire to regress back to her old ways.
Starting over and drawing the line between good and evil proves harder than Sam ever thought.