The Griffins decide to climb Mount Everest after their competitive family friends announce their ambitious plans to hike the legendary mountain.
However, things go awry when the Griffins get stuck on the mountainside in the middle of a massive storm.
On a Halloween-themed night, the Griffins are selected to be a Nielsen family and have their television viewing habits monitored. However, Peter takes his enthusiasm too far when he steals multiple Nielsen boxes and tries to control the airwaves.
Brian learns that Carter Pewterschmidt's company is keeping the cure for cancer from the public in order to drive up profits; Quagmire reveals a secret.
When Brian discovers that Carter Pewterschmidt's pharmaceutical company is withholding the cure for cancer from the public in order to gain more profit, he and Stewie plot to expose the big secret that could change the world. Meanwhile, Quagmire reveals a hair-raising secret of his own.
The criminal who, years ago, shot Joe and left him in a wheelchair, becomes a fugitive. So, Quagmire, Joe and Peter team up to hunt the bad guy down.
After Peter makes Lois feel bad about her age during a surprise birthday party. she decided she needs a younger lease on life.
Peter enjoys the new Lois but soon realizes he can't keep up with her lifestyle.
Meanwhile, Stewie adopts a turtle from the park but soon discovers it has a hidden agenda.
Meg finally asks out the boy she's had a crush on, Kent, but after he reveals he's gay Meg decides she will have him regardless of the cost.
Meanwhile, Stewie think he has a secret admirer.
It's Christmas time again & Peter tells his own version of the Nativity.
To boost Chris' self-esteem, Peter and Lois send him to space camp. When camp ends and the Griffins come to pick Chris up, they accidentally are launched into outer space, and it's up to Chris to land the clan safely back on earth
Brian writes a play that's a hit in Quahog, but his confidence is shaken when he reads a play Stewie wrote that's much better than his. Soon, Stewie's work is Broadway-bound, causing a rift between the two.
When Peter, Quagmire and Joe visit the Harvard University campus, Quagmire accidentally marries a prostitute. In order to get out of his marriage, Quagmire pretends to be lovers with Peter.
Love is in the air on Valentine's Day. Meg dates a guy from the internet, Stewie uses his time machine and falls for a girl in the ‘60s and Peter and Lois decide to stay in bed all day.
Meanwhile, Brian's ex-girlfriends pay him a visit and Quagmire gets in touch with his feminine side.
To buy new sneakers, Chris steals money from Lois' purse. When Meg catches him in the act, she forces him to do all of her chores in exchange for keeping mum.
But Chris finally tires of the pact, and runs away to live with Herbert.
Meanwhile, Stewie and Brian become obsessed with singer Anne Murray (guest-voicing as herself), and visit her to find out the true meaning of "Snowbird"
When the Griffins find themselves in a financial bind, Lois is forced to find a job of her own. She gets discovered by a "voiceover" talent agent named Randy, who actually runs an adult-only phone line and pays his employees generously. As Lois settles into her new gig, she hears Peter's voice on the other end of the line.
When Peter, Quagmire and Joe need a jolt in their mundane lives, they decide to go skydiving. But after an unfortunate accident, Peter ends up in the hospital, where he befriends Mahmoud (guest voice Omid Abtahi), who convinces Peter to convert to Islam.
Quagmire and Joe are suspicious of Mahmoud's intentions and try to stop the friendship from progressing
A bloody murder occurs at Mayor West's mansion, and he is the prime suspect. The mayor is put on trial, and it is up to the citizens of Quahog to determine if he is guilty or not.
When Peter, Quagmire and Joe fly on a private plane to Canada, they crash in the middle of the wilderness, far from civilization.
Peter is chosen to find help, but ends up going missing for two months, only to be found as a feral creature with no ability to communicate intelligently. The Griffins must find a way to bring back Peter to his old self.
After teddy bear Rupert gets recalled, Stewie stops at nothing to get back his beloved best friend. Meanwhile, Peter falls ill and can't compete in his bowling tournament. So Lois fills in for him. But when she gets a little too close to Peter's teammates, he gets jealous.
When the owner of the Clam is killed, the bar closes and Peter, Quagmire and Joe must find a way to save their beloved watering hole.
Meanwhile, Meg gets an after-school job at a funeral home.
When a heightened crime rate strikes the Griffin house with a break in, Peter moves the family to a farm.
Struggling financially, they discover a meth lab in their basement, they decide there's only one way to save the farm.
When Brian wins tickets to a Céline Dion concert he invites Stewie to come along.
After Stewie suggests they take his new experimental transporter, it malfunctions creating an alternate pair of Stewie & Brian leading to one pair having a great trip and the other having a bad.
When Chris make the acquaintance of the daughter of the owner of the Barrington Country Club, the Griffins are introduced to the new club lifestyle much to the chagrin of Carter.
Carter eventually gets kicked out of Barrington and Peter agrees to help him get back in.