In this hug mystery special, The Griffins as well as all the other major characters become trapped in a mansion while they are killed off one by one.
When Brian learns that Rush Limbaugh is going to be at the Quahog Mall for a book-signing, he decides to go down there and give him a piece of his left-wing mind. But when Rush unexpectedly comes to Brian's rescue, Brian has a political change of heart.
After Peter catches Carter having an affair, he is forced into keeping a secret. But when Peter accidentally spills the beans, Lois' mom demands a divorce, and Peter is in charge of Carter's return to bachelorhood.
Peter and Joe team up to execute a series of painful and humiliating Halloween pranks on unsuspecting family, friends and neighbors.
While Brian shows Stewie the ropes of trick-or-treating, Meg sets out to attend her first high school Halloween party with high hopes for the evening.
When Peter receives tickets to a boxing match as a birthday gift, he volunteers Lois to compete. To everyone's surprise, Lois dominates in the ring, and Peter decides to become her fight promoter. Her frustration with Peter turns into motivation in the ring as the housewife turns champion.
Feeling discouraged with the progress of his writing career, Brian decides to throw in the towel until Stewie become his manager and one of his books hits the bestseller list.
Brian and Stewie take their adventures to the North Pole to seek out Santa Claus.
Peter needs a new kidney after his energy-drink addiction causes renal failure. Meanwhile, Chris is chosen to introduce United States President Barack Obama at his school after winning an essay contest. Only thing is, Meg actually wrote the essay.
Lois becomes friends with Joyce Kinney, the new local news anchor, and Joyce convinces Lois to let her do a story on her as the model American housewife.
Brian and Peter are required to attend a 12-step program to deal with their drinking problems; Death gives Peter a glimpse of what life would be like without alcohol.
On the search to find a new hobby, Chris meets a puppeteer named Franz, an old friend of Herbert's.
When Bonnie goes out of town, Meg offers to check in on Joe, but she soon becomes a little too involved and starts freaking everyone out - especially Joe.
Chris, Meg, Peter and Lois all trade places to teach each other a lesson.
When the local dry cleaner loses Peter's favorite white shirt, he goes ballistic.
Meanwhile, Brian tries to score on a date with a new friend, Denise, but ends up striking out.
When Mayor West marries Lois' sister, Carol, they move into the Griffin's house to be one big happy family.
To make room for everyone, Stewie is bumped out of his room and takes over Chris' room, but not everyone is annoyed by the change.
Stewie and Brian go back in time to stop Bertram from killing Leonardo da Vinci.
Bonnie and Lois take a little trip to Paris, but Bonnie crosses the line in the City of Love.
Meanwhile, Peter home schools Chris and Meg using some unorthodox teaching methods.
After a third power blackout, the family (albeit reluctantly) tells the story of "Star Wars: Return of the Jedi".