America's favorite Midwestern family travels to New York City in search of Bart's long-lost love Mary Spuckler who he wants to reconnect with since she has left Springfield and her hillbilly family there to reinvent herself in the big apple.
Back in ancient times where a Mayan Homer and Marge are witnesses to the prediction by ancient calendar makers that 2012 will be the end of the world. In "The Greatest Story Ever Holed," theSpringfield Subatomic Supercollider creates a black hole that terrorizes the city, sucking up everything in its path. Then, in "UNnormal Activity" the familyinstalls cameras all over the house when things start to go bump in the night and Marge discovers it may have to do with an unholy pact she made some years prior. Then in"Bart & Homer's Excellent Adventure," Bart travels to 1974 to buy a comic book at cover price but inadvertently disrupts Homer and Marge's courtship, leading Marge to end up with Artie Ziff.
When Marge's car falls into a sink hole, she buys the perfect replacement to fit her family of five. But she quickly grows to hate it because, as she tells a shocked Homer, the car would be too small if she wanted to have another baby.
Meanwhile Bart and his friends are determined to find out what secret Lisa is keeping when Bart finds her cryptic messages and follows her sneaking off downtown for covert meetings after school.
After forgetting to visit Grampa, Homer and Marge discover he is missing. Their search leads them to his wife, Rita LaFleur.
Meanwhile, after Homer puts Lisa's college fund on a Poker site, Lisa attempts to double her money.
Homer is shocked to discover that his bowling teammate Dan Gillick, is an accountant for Fat Tony and his mob. When the government finally catches up with Fat Tony and he is forced to serve time... on a jury, he names Dan as his temporary replacement. Meanwhile, Lisa adds insects to her vegetarian diet after passing out during a saxophone solo, but starts questioning her decision when bugs start pleading for mercy in her dreams.
Lisa tries to cheer up a down-in-the-dumps Homer by winning him a "MyPad" at the school auction. But he falls back into a funk when he breaks the magical tablet device - until Ned Flanders discovers a miracle tree in the Simpsons' backyard with bark that spells the word "HOPE"
A "cool family" from Portland moves in next door to the Simpsons. Homer is desperate to befriend them, while Marge is skeptical, thinking that being cool is not all it's cracked up to be.
When a fire at the retirement home forces Grampa to move back in with the Simpsons, Homer throws out his back on moving day.
While "resting" at home, he gets hooked on the super-addictive tablet game, "Villageville".
And, in his distraction, he loses the family dog, Santa's Little Helper. Everyone is angry with Homer for not seeming to care about the missing dog, but Grampa tells them the story of Homer's long-lost childhood pup, Bongo
Homer joins the "Springfield Preppers", an off-the-grid survivalist group whose leader has set up a top-secret retreat outside of town to prepare for the end of the world. But Marge grows skeptical of the group's alarmist shenanigans.
When Springfield Elementary is threatened with closure because of low standardized test scores, the fate of the school rests on one student who missed the test, and who must raise the average above the minimum threshold: Bart Simpson.
Meanwhile, Homer finds a parking meter at a local dump, and starts deploying it around Springfield to fleece unwitting parkers of their quarters.
After surviving a tornado, Marge and Homer seek out guardians for the kids, in case the worst should happen. They first turn to friends and family, including Homer's half-brother, Herb Powell with whom to entrust their kids, but when Bart and Lisa fall in love with a super-cool couple, Mav and Portia, Marge starts to question their potential guardians' true motivations.
Bart's heart strings are pulled once again when Mary Spuckler returns to Springfield. But his failure to pay her enough attention strains their relationship. Marge, too, puts Homer in the dog house.
Bart and Milhouse explore the perks of being an adult when a shaving accident leaves Milhouse looking exactly like his father, Kirk.
Marge fears Maggie is slipping into the clutches of children's television.
Homer's obsession with the TV show "Storage Battles" leads the family to discover Grampa's past identity as "Gorgeous Godfrey", the most feared, villainous man in pro-wrestling history.
What's more amazing, he was once revered by a young Montgomery Burns, who now convinces Grampa to get back in the ring. But when Bart starts to adopt some of his grandfather's former cheating ways, Grampa must reconcile with his past before it's too late.
Flanders becomes jealous when his laid-back parents start to prefer Homer's company over his and he faces unbearable guilt after punching Homer in the eye, as he desperately tries to reconcile with him.
Meanwhile, Lisa is distressed by her new substitute teacher (guest voice Tina Fey), who bullies her for no apparent reason
Bart is falsely accused of pulling a prank on Easter involving the school marching band and stuffing rotten eggs in the brass section's horns, and Lisa must step in as his attorney to defend her brother.
Meanwhile, Mr. Burns attempts to fulfill his lifelong dream of becoming a superhero, Fruit Bat Man
Homer's behavior once again lands him in hot water with Marge and he needs to fathom a way to save his marriage, while a dose of "A Streetcar Named Desire" drives Milhouse to affect a Marlon Brando-esque bad-boy demeanor in an effort to impress Lisa.
Homer is recruited to be a church deacon by the trendy new reverend in town (guest voice Norton). But Bart asks Flanders to help him track down their former pastor, Reverend Lovejoy, when Homer starts to embrace the faith a little too seriously.
Meanwhile, Marge finds out her dry cleaners mistakenly swapped her wedding dress with one of Krusty's costumes.
Moe is flying high after venture capitalists take a shine to his homemade whiskey, while Grampa, after injuring himself babysitting Bart, decides he'd rather be looked after by his grandson than be at the nursing home. Also, Lisa voices her displeasure at a hologram of music legend Bleeding Gums Murphy, and Sonny Rollins (as himself) shows up to ask her to stop all that jazz about boycotting a record label.
Marge encourages Bart to explore his creative side, and his initial reticence quickly subsides when Marge hires Slava's beautiful daughter, Zhenya, as his new piano instructor.
Meanwhile, Homer is shocked when he loses the last two remaining hairs on his head, and employs a wide variety of headgear to try and keep his newfound baldness a secret from Marge.
Homer, Moe, Lenny and Carl win 0,000 in the Springfield Lottery. But when Carl takes off to Iceland - his homeland - with all the winnings, the guys embark on a Nordic adventure to get the cash back.
While trying to obtain a cupcake inspired anniversary gift for Homer, she inadvertently signs up for a dating site for married people who want extra marital relations.
When she thinks Homer has forgotten their anniversary, she starts talking to Ben, a man who shares her fondness for British drama.
Meanwhile, Homer hasn't forgotten & decides to remind Marge of their first anniversary by refurbishing an old mall train.