Dr. Helen Magnus is one of the first female doctors in the Royal College during Victorian England. She was engaged to Jack the Ripper, and also has a daughter from him, Ashley. However, Ashley does not yet know that her father is Jack. Dr. Magnus' father started a sanctuary for supernatural creatures, collected from all over the world. In her work with these creatures, Dr. Magnus has received age longevity. While tracking a dangerous young man she crosses paths with a young psychiatric resident Dr. Will Zimmerman who may have what it takes to become her new protégé.