Sit Down, Shut Up is an animated comedy about the lives of eight staff members at a high school in a small northeastern fishing town. Sue Sezno is the acting principal - the principal is recovering from a series of escape attempts unfortunate accidents - and a woman who frequently says "no".
Next in line is vice principal Stuart Prozackian who has a never ending positive and upbeat attitude, most likely due to performance-enhancing medication the other teachers secretly put him on. It's been said that those who can teach teach gym, and that saying sums up the life of Larry Slimp, who has been exiled to the gym. Larry has a crush on Miracle Grohe, the science teacher who balances science with her superficial grasp on spirituality.
Rounding out the staff is Willard Deutschebog, an aging German teacher; Helen Klench, the uptight librarian angered that her life's work in research and archiving can be outdone by a simple Google search; Andrew Sapien, the flamboyant drama teacher; Ennis Hofftard, a self-obsessed body builder; and Happy, the custodian.