Julia is forced to make a drastic decision when she finds out that Isaac has been secretly working with Leon for advice on his current patients. Meanwhile, Roxy takes her new protégé back to her old gym, where she runs into old enemies from her gymnastics days, Tim is on high alert when Edie misses a family event to "work" all weekend and Julia steps back into the dating scene.
Only child Julia Bechley finds her life turned upside down when her father reveals that, over the course of his prize-winning career as a pioneering fertility doctor, he used his own sperm to conceive upward of 100 children. Reeling from this explosive revelation, Julia discovers two new sisters - her former best friend, Edie Palmer, and an ex-Olympic athlete, Roxy Doyle. As these three young women begin to embrace their new reality, Julia must figure out what life is like without her father by her side; Edie comes to grips with her burgeoning sexuality as her marriage falters; and Roxy faces adulthood out of the spotlight. Against all odds, the three women will attempt to form an nontraditional bond as sisters, even as they must welcome a tidal wave of new siblings into their rapidly expanding family.