Mel and Maggie are learning to navigate life without their sister Macy - Mel distracts herself with new flings at magical hotspot, the Blue Camellia bar, while Maggie is taking on more than her share of demon hunting. Meanwhile, Harry is struggling, mourning his lost love, and Jordan has teamed up with Maggie while navigating his newfound magical powers. Across the country in Philadelphia, an unsuspecting young woman... is living her life... mechanic by day, muralist by night... when she's suddenly thrust into a new world, coming face to face with the women she's inexplicably seen in her dreams. Just as Mel, Maggie and Harry are uncovering information about this mysterious new person, Josefina goes missing on her way to a pixie-pledging ceremony, and Mel and Maggie must rely on their "new third" to help their cousin... and find out if she is indeed the other Charmed One that they were told was "out there somewhere".
Three months after their mother is killed by an unknown demonic force, sisters Mel and Maggie discover that they have an older half-sister, Macy. The first time the sisters are under the same roof, they unexpectedly start exhibiting new magical abilities; the eldest Macy receives the power of telekinesis, middle sister Mel can freeze time, and the youngest Maggie can hear people's thoughts.
Soon after, Harry Greenwood gathers all three sisters together and reveals to them that they are witches, as was their mother. Marisol had bound her daughters' powers when they were born so they could live normal lives, and was in the process of unbinding those powers on the night she was cuddled.
The sisters ultimately accept their new destiny as The Charmed Ones, the most powerful trio of witches who protect innocents and vanquish supernatural demons.