Desna and her girls take pride in doing nails at the Nail Artisans of Manatee County, but amidst painting hooves and dreaming of a better life, she finds herself entangled in a money laundering scheme with the Dixie Mafia.
Following their entanglement with Roller, Desna and Virginia desperately prepare a cover story to tell the girls and the Dixie Mafia. Desna's dream salon is falling out of her grasp.
As Virginia's lies deepen, Desna plays catch-up covering their tracks. Desna still has a small shot at her dream salon, and with the help of her crew, she is determined to get it.
Haunted by recent events with Roller, Desna is doubly desperate to get out from under Uncle Daddy's thumb. Meanwhile, Bryce drifts deeper into the Dixie Mafia, which Jennifer isn't happy about. Polly reunites with her former gold-digging "friend", while Quiet Ann is in a lady-mess of her own. Meanwhile, Dr. Ken finds himself in a world of trouble.
Desna and Jennifer may be Dr. Ken's only hope, as Bryce wrongly accuses him of a heinous crime. Dean sees a disturbing billboard ad that hits too close to home, leaving Desna to cope with the dark aftermath. Meanwhile, Virginia and Desna are forced to go to Polly for help to rid the world of two horrible birds from Desna's past, with one well-aimed stone.
The girls go to their fancy new salon for the first time. Desna and crew decide to compete in Florida's premiere nail design competition for a cash prize. Feeling left out, Virginia does something shocking to get some of life's finer things.
After the big nail competition, Desna may finally get out from Uncle Daddy's grasp. Jennifer struggles knowing Desna's dark secret, while Polly discovers her previously unknown maternal instincts. Meanwhile, Dean may have found his first feelings of romantic love and makes a discovery that threatens to destroy everyone he knows and loves.
With a shocking revelation affecting the entire crew, Jennifer finds unexpected solace in her square-dancing instructor, Hank. Polly uses all of her powers of bad for good, for the first time.
With the clock ticking, Desna is scrambling to get out of her worst trouble yet. Determined, she goes searching for the truth with her crew right behind her, save for Jennifer, who is learning how to cope as a Dixie Mafia wife.
In the season finale, following a harrowing escape from Roller's grasp, Desna is on the run with Roller close behind, running from the Russians. Dean, Polly, and Virginia frantically search for Desna before time runs out. Meanwhile, Jennifer gets more involved with Hank.