Lynette returns home from the hospital. Gabrielle decides to get back into modelling and travels to New York. Susan comes home to find Austin and Julie making out on her couch. Bree meets her antagonistic mother-in-law Gloria (guest star Dixie Carter), with whom Orson is in a quarrel. Detective Ridley has Mike's house searched.
The series began with Mary Alice Young leaving her perfect house in the loveliest of suburbs - and ending it all. Now she takes us into the lives of her family, friends and neighbors, commenting from her elevated P.O.V.
Her circle of girlfriends on Wisteria Lane include Susan Mayer, the divorcee and single mom who will go to extraordinary lengths for love; Lynette Scavo, who recently went from being a stay-at-home mother of four back to her fast track career in advertising; Bree Van De Kamp, Martha Stewart on steroids, whose recent widowhood has completely reeked havoc on her perfect life; and Gabrielle Solis, the ex-model with everything she's ever wanted - a rich husband, a big house, and now a baby to go with it all... the problem is she's not sure who the father is; and serial divorcee Edie Britt, the free spirited real estate maven whose love life has everyone buzzing. Enter newcomer Betty Applewhite and her handsome teenage son, Matthew, who mysteriously moved into a house they'd never seen in the middle of the night.
Then there are the men: Mike Delfino, a supposedly widowed plumber who has won Susan's heart; Lynette's adorable husband, Tom, who volunteered to be "Mr. Mom" so his wife can go back to work; Gabrielle's better half, Carlos, who is currently in jail and recently learned of his wife's infidelities with John, the gardener; and Mary Alice's widowed husband, Paul, who is on the run from the demons in his past.
From her unique vantage point, Mary Alice sees more now than she ever did alive, and she's planning to share all the delicious secrets that hide behind every neighbor's closed door in this seemingly perfect American suburb.