Amy's past comes back to haunt her when a desperate father sacrifices everything to secure his daughter's heart transplant.

Amy grapples with having memories while treating a mother-to-be with a mysterious condition. Also, Dr. Joan Ridley, Amy's mentor, visits Westside.

A patient forces Amy to confront the realities of medical tourism, TJ helps a veteran with his prosthetic and Joan drops a bombshell.

An outdated medical proxy form creates tension between a patient's ex-husband and current partner. Amy, Jake, and new intern Hannah investigate a college student's sudden blindness.

A popular weight loss medication reveals the cracks in a couple's relationship and two sisters face an unexpected diagnosis.

Amy treats a Chaplain who helps her reconcile with the past, while Michael is under investigation for his actions during the hostage crisis. Also, TJ returns to work and treats a prisoner and Hannah's brother shows up with a plan.

Amy and Gina, with an assist from Jake, team up to help a victim of domestic abuse, while TJ finds himself in the spotlight when he, Sonya and Liz treat a social media influencer. Also, Hannah and Charlie conspire to destroy Amy.

After receiving tragic news, Jake refuses to give up on a beloved patient, landing himself in conflict with several Westside surgeons and when Amy's neuro tests elicit memories of Danny, she pushes herself too far. Also, TJ and Sonya treat Dr. Peter Douglas for a painful condition and learn more about him than they ever wanted to know.

At Jake's father's funeral, grief helps clarify his feelings for Amy, and a flashback to the pandemic reveals the truth about why he stayed at Westside. To Hannah's surprise and dismay, Charlie goes too far with their plan to destroy Amy, causing explosive repercussions.