Amy's past comes back to haunt her when a desperate father sacrifices everything to secure his daughter's heart transplant.

Amy grapples with having memories while treating a mother-to-be with a mysterious condition. Also, Dr. Joan Ridley, Amy's mentor, visits Westside.

A patient forces Amy to confront the realities of medical tourism, TJ helps a veteran with his prosthetic and Joan drops a bombshell.

An outdated medical proxy form creates tension between a patient's ex-husband and current partner. Amy, Jake, and new intern Hannah investigate a college student's sudden blindness.

A popular weight loss medication reveals the cracks in a couple's relationship and two sisters face an unexpected diagnosis.

Amy treats a Chaplain who helps her reconcile with the past, while Michael is under investigation for his actions during the hostage crisis. Also, TJ returns to work and treats a prisoner and Hannah's brother shows up with a plan.

Amy and Gina, with an assist from Jake, team up to help a victim of domestic abuse, while TJ finds himself in the spotlight when he, Sonya and Liz treat a social media influencer. Also, Hannah and Charlie conspire to destroy Amy.

After receiving tragic news, Jake refuses to give up on a beloved patient, landing himself in conflict with several Westside surgeons and when Amy's neuro tests elicit memories of Danny, she pushes herself too far. Also, TJ and Sonya treat Dr. Peter Douglas for a painful condition and learn more about him than they ever wanted to know.

Grief helps clarify Jake's feelings for Amy, and a flashback to the pandemic reveals the truth about why he stayed at Westside. To Hannah's surprise and dismay, Charlie goes too far with their plan to destroy Amy, causing explosive repercussions.

With the search underway to find out the truth about Amy's hacked accounts, she and Sonya butt heads while treating a homeless patient with a crush injury who was dumped in front of Westside Hospital. Jake and TJ help a distraught mother figure out why her daughter is in a coma. Hannah cares for a charming high school athlete, while working with Charlie to cover their tracks by infiltrating the hospital computer system. Unfortunately, those efforts result in major collateral damage.

The search for Amy's hacker intensifies when the hospital finally brings in the FBI. Hannah, devastated by the passing of her patient, works with Amy to treat a sick older man whose daughter believes has been poisoned. Meanwhile, Sonya and TJ examine middle school kids for scoliosis, and discover a child with a different ailment and a home situation that may have caused it to get much worse.

Charlie fights for his life at Westside with Hannah by his side. The Board launches an internal investigation into Brian Clark's resignation, putting everyone in the hot seat and motivating Amy to figure out what happened before the hospital can make her a scapegoat. A familiar face returns to Westside and Amy is not happy about it.

The race for Chief resident intensifies as Joan tasks Amy and Sonya with evaluating each other's case work. Amy tends to a politician with a disability. Sonya struggles to find a solution to her combative patient's abdominal pain. Michael's parents come to town.

Amy and Jake treat an expectant mother injured during a robbery. Michael is challenged to open up when Katie's therapist invites him and Amy to a session. TJ and Sonya help Julie navigate a mysterious illness and an unexpected romance.

While navigating the fallout from Katie's secret, Amy treats a critically ill patient with a dark one of her own. Gina and Jake evaluate a world-class poker player. Sonya and TJ investigate their theory behind Joan's frequent absences and Richard returns with a trick up his sleeve.

Met with hostility upon his return, Richard looks to redeem himself while treating an overworked food delivery worker. Sonya and TJ enlist Jake's help with the delicate Joan situation. Amy and TJ take on the case of a well-known medical malpractice lawyer, leading to unexpected complications.

After a tragic accident, one of Joan's oldest friends is rushed to Minneapolis for treatment, forcing Amy to confront her about her illness. Meanwhile, Richard and TJ find themselves at odds when they treat a tech bro who thrives on pushing boundaries and Michael tries to pick up the pieces in the wake of his fractured marriage.

When Amy and Michael take Katie on a road trip to her college orientation, they pass a familiar campsite and decide to stop and hike the trail. The journey quickly becomes harrowing when they discover an injured man whose life hangs in the balance. Stranded in the middle of nowhere, with no cell service, it's up to the three of them to somehow save him.

On her last day at Westside, Joan chooses an unlikely successor, crowns a Chief Resident and imparts some final wisdom to the next generation. Gina steps in to help TJ's patient, a foster child suffering from rheumatoid arthritis. Amy and Jake's tension intensifies while treating a pregnant teen caught between her divorced parents.

On Michael's first day as Chief of Internal Medicine, Joan arrives at the hospital as a patient in dire straits. Amy, determined to save her, clashes repeatedly with Richard over Joan's treatment plan. Meanwhile, Gina makes a nearly impossible medical decision for a young patient and Liz fights for her allegations against Richard to be taken seriously.

A mysterious, fast-acting and extremely deadly virus triggers an emergency lockdown on the 6th floor of Westside Hospital.

In an effort to save a crashing Richard from a deadly virus, Amy gets infected with it. Michael and the team work tirelessly to help her and the other patients, but their experimental treatments fail, and Amy becomes critically ill.