Santanico and Richie are outside Houston, living like Bonnie and Clyde; Seth and Kate are scraping by South of the Border; and Freddie Gonzalez is protecting his wife and young daughter in a Houston suburb. And Carlos Madrigal and Scott Fuller emerge from the Titty Twister, changed men. They will all come together once again - this time facing off against an even bigger threat.
Seth and Kate stage a heist, while Gonzalez endures frightening visions that lead to a grisly discovery, and back at the Twister, Malvado's plans are set into motion by Carlo's emergence from the labyrinth.
Richie and Santanico pose as sex traffickers to infiltrate Malvado's food supply, while Sonja forces Seth to kick his drug habit. Meanwhile, Freddie faces off with Sex Machine, who attacks his family to retrieve the codex.
Kate hunts down Scott in Bethel before he can exact revenge. In Houston, Richie and Santanico find themselves deep in the flesh trade, while Seth tries to get back in Uncle Eddie's good graces.
The Gecko brothers finally call a truce and work together to find Malvado's headquarters; Carlos, unhinged from the Labyrinth, abducts Santanico and claims her for himself. And Kate enlists Freddie's help as she attempts to save her brother.
Following the trail of the mass grave, Freddie and Kate uncover epic secrets and confront Oculto, a reclusive and dangerous Lord. Seth and Richie take the girls on a double date, and Carlos lets go of the past.
Uncle Eddie helps Richie and Seth make a plan to complete Santanico's revenge. Meanwhile, Freddie and Kate encounter an unexpected foe following Malvado's attack.
As the pieces of the big job fall into place, the uneasy trust between brothers and partners crumbles in the light of the betrayals and new loyalties.
Santanico confronts Malvado with Seth's help; Richie and Kate must stop Carlos and Scott from overturning the ancient prophecy and taking control of a powerful evil.
Seth and Santanico clash with Richie over his betrayal, while Carlos and Scott aim to take Malvado's empire and unleash culebra frenzy on the world.