When a couple splits up, the real question is who gets to keep the friends? After Alex leaves Dave at the altar, their breakup complicate their friend's lives and makes everyone question their own choices.
Now that Dave's moved out, Alex starts looking for a new roommate with help from her sister who doesn't think she's a very good judge of people.
Brad resists Jane's idea that they befriend a new couple she's picked out. Max and Dave are at a loss to figure out why food and other items keep going missing from their apartment until Alex tells Max that Dave walks and eats in his sleep.
Max's parents are in town and the gang tries to convince Max to tell them he's gay rather than yet again have to find someone to pose as his girlfriend. Meanwhile, Penny meets Doug who appears to be the man of her dreams.
Brad's dad, who's in town for some medical exams, gets a clean bill of health from the doctor and proceeds to let loose much to Brad's discomfort. Penny who once studied in Italy is excited when she meets a gorgeous Italian guy. Problem is, he speaks no English and she finds she can only speak Italian when she's drunk.
Max doesn't act very grateful when Brad tries to hook him up with a guy from work and Penny has second thoughts after asking Jane along to her martial arts class. Dave misses his old digs as he adjusts to living with Max so he starts hanging out at Alex's place helping out with odd jobs.
Dave shocks everyone by quitting his job and plans to open a restaurant; Jane and Max face off in silly challenges; Penny is exhausted by trying to keep up with her new boyfriend's friends.
Alex and Dave's his-and-hers tattoos come back to haunt them now that they're no longer a couple; jane meddles in Max's love life when she thinks he's passing on the perfect guy; and Brad takes a stand at Rosalita's against the world's worst waiter, with unexpected results.
Dave's excited that the high school teacher who had a big influence on his life is in town. But when Penny goes on a date with Alan, she realizes he isn't quite what Dave thinks. Max organizes a protest against the coffee chain that has moved into the shop next to Alex's.
Alex drags Penny out on a series of girls' night outs. Dave convinces Max to help him hunt down the guy who ruined his wedding. Jane and Brad have a night out on the town.
Alex and Dave want to convince the gang they can be "friends" so they round everyone up for a Barefoot Pedaler concert, but the big night doesn't go off as planned.
A sudden invitation to an old friend's upcoming wedding brings out mixed feelings and unexpected consequences. The bride has the unpleasant feeling that Alex is bad luck while Brad and Jane find something unexpected about their marriage.
When Jane thinks Alex is trying to steal her thunder with Jane's literacy group, their old sibling rivalry heats up. Meanwhile, Dave dates an attractive women's Lacrosse coach with a strange quirk, and Penny finally gets an assistant and is determined to be the "cool boss", with disastrous results.