Murphy is a hard-living, hard-drinking, disaffected twenty-something with a penchant for cigarettes and casual sex. She's also blind. Murphy lives with her supportive best friend, Jess, and-more reluctantly-her trusty guide dog, Pretzel, whose presence she resents. Her parents, Hank and Joy, own a guide dog school, a venture they opened hoping it would give Murphy a job with some purpose. Murphy's closest friend is a sweet teenager named Tyson, whose kindness and intelligence are currently going to waste as he deals drugs on the street for his older cousin, Darnell. Murphy's life comes crashing down when, while out for a walk with Pretzel, she stumbles upon what she's sure is the lifeless body of Tyson in the alley outside her apartment. But when the police arrive, including a salt-of-the-earth detective named Dean, there is no body to be found-and with Murphy not exactly sober, the police aren't especially inclined to investigate. Murphy is devastated, and the only thing holding her back from spiraling downward even further is her resolve to learn what happened to Tyson.
After Murphy's latest one night stand calls her "Mommy", she develops a rather unexpected lead in Tyson's case; Tyson's mother. Her lead provides rather daunting results so she tracks down Tyson's cousin Darnell and encounters his "business associate" Max who is immediately smitten with Murphy. Meanwhile, Chloe thinks it's time for her father Dean to start a dating profile. Lastly, Murphy helps Jess pick out a special gift for her girlfriend Vanessa.
Murphy enlists an unwitting Felix to help locate Tyson's girlfriend, Kira; Murphy and Felix their first heart-to-heart under the bleachers and Dean does his best to be there for Chloe as she experience's a rite of passage.
Murphy discovers she may not have known Tyson as well as she thought she did. Meanwhile, it's puppy graduation day at Guiding Hope, and one of the foster's is having a hard time letting go.
Jess reluctantly agrees to let Murphy go alone with Max on a day trip. While traveling, Murphy has flashback of memories of Tyson. Meanwhile, Jess and Joy realize they may have more in common than they thought.
Murphy, unable to deal with things, begins to push everyone away, including Max. Meanwhile, Murphy and Jess have a heart-to-heart.
While hanging out with Max in his food truck, Murphy is shocked to hear a familiar voice screaming outside; Murphy offers to watch Chloe so Dean can go on a date, but things get a little crazy after she does the one thing he asks her not to do. Lastly, Murphy's worlds of Max and Darnell and Guiding Hope begin to collide.
Murphy finally starts opening up to Max. Meanwhile, Murphy, Max and Darnell tep up to help Jess. Lastly, Felix makes an interesting decision.
With Jess focusing all of her attention on Vanessa, Murphy begins to feel neglected. To make matters worse, tensions begin to rise between her and Max. Meanwhile, Jules is forced to make a quick decision.
Murphy and Jess are both going through similar situations, but they are handling things very differently. Meanwhile, Felix and Jess share a beautiful moment together.
Murphy and Jess borrow the Guiding Hope van to search for Max, leaving Felix in a precarious position. Meanwhile, Dean receives some surprising news.
It's Murphy's first birthday since Tyson was killed and she is feeling more isolated than ever.
Things begin to take an interesting turn between Murphy and Dean. Murphy figures out what happened to her friend.