In failing health, Joe's grandmother Sofia begs him to come visit her one last time for her birthday, and to bring his beautiful wife Tiffany along. Since Joe never got around to telling "Nona" he and Tiffany got divorced, he's forced to beg Mel to pretend to be his trampy ex. Soon, Joe and Mel are on the road to Jersey with Lennox and Ryder tagging along.
Once there, they meet Joe's colorful mother Gloria, his sister Theresa and the formidable Sofia. Sensing something is amiss with her grandson and his "wife", Sofia resorts to trickery to see them repair their marriage by any means necessary. What started out as a silly ruse soon makes a wrong turn, and leaves Joe and Mel confused as to where they stand with each other.
Meanwhile, Joe's nephew Marco makes the moves on Lennox. And Ryder enjoys being treated like a king until he's asked to perform a favor for the family.
Melissa is a grown-up former wild child of a political family who is now a local politician herself. When her sister ends up in prison and brother-in-law flees after a scandal hits, Mel must take responsibility for her teenaged niece Lennox and pre-adolescent nephew Ryder. Spread too thin to manage by herself, help comes in the unlikely form of Joe who, desperate for a job, moves in and becomes the family's manny.