Frank pursues a hugger who kidnaps teenagers from an upper middle-class neighborhood and forces them to drink human blood. After one is killed and the other is returned home unharmed because his father admitted to making a mistake, Frank is forced to set up a trap to capture the hugger before he can harm the third victim.
Frank has a special ability to see into the minds of serial killers. Working for a mysterious organization called the Millennium Group, who take a special interest in serial killers and the millennial end of the world prophecy.
During the first season, Frank lives with his wife Catherine and daughter Jordan in Seattle. The show focuses on Frank's work as a profiler. The first season focuses most of Franks' time trying to solve serial murder cases.
During the second season, the show primarily on Frank's relationship with the Millennium Group. After separating from his wife after a violent rescue of her from a stalker. Frank learns that the Millennium Group is a secret society that believes that the world is coming to an end. During this season, Frank spends much of his time working with Millennium Group member Peter Watts and fellow investigator Laura Means.
After the death of his wife at the end of the second season, Frank severs all connection with the Millennium Group and returns to work with the FBI. With the help of special agent Emma Hollis, he begins to investiagate the Millennium Group itself.